Transport systems comparative genomics

Ren, Q. and Paulsen, I.T. (2007) Large-scale comparative genomic analyses of cytoplasmic membrane transport systems in prokaryotes. Journal of Molecular Microbiology and Biotechnology, 12 (3—4), 165-179. 

Lactic Acid Bacteria Comparative Genomic Analyses of Transport Systems... 

Lactic Acid Bacteria Comparative Genomic Anaiyses of Transport Systems 61 Table 4.4. Summary of functionally characterized secondary carriers in LAB. 

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Lorca, G., Reddy, L., Nguyen, A., et al. (2010) Lactic acid bacteria comparative genomic analyses of transport systems, in Biotechnology of Lactic Acid Bacteria Novel Applications ((eds) F. Mozzi, R. R. Raya, and G. M. Vignolo), Wiley-Blackwell, Oxford, UK. 

Clearly, genome-wide studies contribute to a better understanding why differences in absorption along the intestine, and between in vitro and in vivo situations, can be expected. These studies could on the one hand confirm that the most widely used in vitro system to study drug absorption, namely, the Caco-2 cells, may not always be very accurate in predicting uptake rates for a new compound. On the other hand, it has to be noted that compared to other in vitro systems, which are being used to study transport in liver and kidney, the Caco-2 cells correlate certainly the best with the in vivo system with respect to the mRNA expression of transporters [3],... 

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