Combinatorial libraries applications

MA Gallop, RW Baii et, WJ Dower, SPA Fodor, EM Gordon. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 37 1233-1251, 1994. 

From Cortese, R., 1996. Combinatorial Librarie.s Syntlre.si.s, Screening and Application Potential. Berlin Walter de Gruyter.)... 

Mason JS, Morize 1, Menard PR, Cheney DL, Hulme C, Labaudiniere RF. New 4-point pharmacophore method for molecular similarity and diversity applications Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures. I Med Chem 1999 42 3251-64. 

Lee, M.L. Schneider, G. (2001) Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs Application in the Design of Natural Product-Based Combinatorial Libraries. Journal of Combinatorial Chemistry, 3, 284-289. 

Closely related to the use of PSA in virtual screening is its application in the design of combinatorial libraries with optimal properties. These applications are reviewed further in Refs. [46, 47], for example. 

I High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries... 

Combinatorial chemistry, 7 380-434 8 400—401 13 283-284. See also High-throughput experimentation applications, 7 381-383 commercial environment, 7 387-389 methodology, 7 383-387 microwaves in, 16 548-552 nomenclature, 7 380 polymers, 7 405—413 Combinatorial libraries, 12 515-517 Combinatorial methods, 7 380 Combinatorial optimization approach, in computer-aided molecular design, 26 1037... 

We prepared a combinatorial library that satisfied the following criteria (1) the chemistry was general and applicable to a wide range of substrates (2) the yields of all the transformations were high or the reactions were amenable to repetitive cycling under the reaction conditions to drive reactions to completion (3) the reaction profiles were clean, minimizing the production of resin-bound impurities and (4) the synthetic sequence minimized the number of chemical steps on solid... 

The Sulfoxide Glycosylation Method and its Application to Solid-Phase Oligosaccharide Synthesis and the Generation of Combinatorial Libraries... 

An important requirement for the successful application of the combinatorial library approach to the drug discovery process, is the ability to utilize the library in high-throughput screening (HTS) procedures. HTS screening of glycopeptide... 

There has been significant advancement in the applications of NMR to the development of small-molecule pharmaceutical products. For example, advances in NMR automation (e.g., flow-injection analysis) and directly coupled methods (e.g., LC-MS-NMR analysis) have made analysis and characterization of small-molecule drugs much easier.23 25 These improvements have helped chemists to develop and characterize small-molecule combinatorial libraries and to screen for active compounds.4 6 It is likely some of these techniques can also be used in biopharmaceutical product development. 

Leach, A.R., and Taylor, R. Further development of a genetic algorithm for ligand docking and its application to screening combinatorial libraries. ACS Symp. Ser. Am. Chem. Soc. 1999, 719, 271-291. 

Horvath, D. In Combinatorial Library Design and Evaluation. Principles, Software Tools, and Applications in Drug Discovery, Ghose, A.K. and ViSWANADHAN, V.N. (Eds). Marcel Dekker, New York, 2001, 429-472. 

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