Combinatorial chemistry Subject

Parallel to these developments in combinatorial chemistry, microwave-enhanced organic synthesis has attracted a substantial amount of attention in recent years. As evidenced from the other chapters in this book and the large number of review articles available on this subject [7-14], high-speed microwave-assisted synthesis has... 

As combinatorial chemistry has been fully integrated into the modern drug discovery process, more computational search methodologies against large virtual combinatorial compound spaces have been steadily developed in recent years (11-16). A detailed summary and comparison of those published methods are reported in the Section 5 and in Table 13.6. A good review on this subject could also be found in the publication by Boehm and coworkers (16). 

A more random approach to discovering a lead is the combinatorial chemistry approach (see Chapter 6). This uses a simultaneous multiple synthesis technique to produce large numbers of potential leads. These potential leads are subjected to rapid high throughput biological screening to identify the most active lead compounds. Once identified, these lead compounds are subject to further development. 

This review has only lightly touched upon the topic of support stability under various reaction conditions. The main reason for this is that very little has been written on the subject. Many of those developing new supports have primarily done so for the fields of solid-phase peptide and/or oligonucleotide synthesis, areas which encompass a very narrow range of reaction conditions. As the field of combinatorial chemistry matures and new reaction types are attempted, an overall stability profile will gradually emerge. 

This subject will not be extensively covered in this review because peptide combinatorial chemistry is fully treated elsewhere in this book [13]. Only a few important contributions will be mentioned Nikolaiev et al. [14] reported a general method for peptide encoding of nonsequenceable polymers using... 

Combinatorial chemistry can produce products that reach the marketplace relatively quickly. Although the drug leads produced by combinatorial chemistry are subject to the same long development times as leads generated by other methods, the technology also delivers products, such as affinity ligands, and the dedicated instrumentation and software that achieve sales immediately. 

A diverse population of nucleic acid molecules can be synthesized in the laboratory by the process of combinatorial chemistry, which rapidly produces large populations of a particular type of molecule such as a nucleic acid. A population of molecules of a given size can be generated randomly so that many or all possible sequences are present in the mixture. When an initial population has been generated, it is subjected to a selection process that isolates specific molecules with desired binding or reactivity properties. 

A different extractive work-up is based on fluorous biphasic systems. This concept was first introduced for fhe recovery of rhodium complexes from hydroformylation processes [13] and was soon extended to separation procedures in combinatorial chemistry [14]. It has been fhe subject of several reviews [15-21]. 

Since I edited Combinatorial Peptide and Nonpeptide Libraries - the first comprehensive book on the subject - in 1996, progress in the field of combinatorial chemistry has been truly dramatic. However, before I began to write this preface, I looked back and found the early work by no means outdated - as evidenced by the number of complimentary letters received from satisfied readers. A number of excellent books on combinatorial chemistry have appeared since then, covering different aspects of the subject. However, despite this earlier boom , I was encouraged to edit a second volume, and recognized that soon there will be very little overlap of Combinatorial Chemistry with the contents of other such books. 

Combinatorial Chemistry begins with a general overview on recent advances in the subject, with expert surveys provided on selected solid-phase organic reactions and - for the first time - also on solution-phase combinatorial chemistry. These chapters are followed by a detailed survey of the broad research into multicomponent reactions. 

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