Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Combinatorial chemistry split method

The major impetus for the development of solid phase synthesis centers around applications in combinatorial chemistry. The notion that new drug leads and catalysts can be discovered in a high tiuoughput fashion has been demonstrated many times over as is evidenced from the number of publications that have arisen (see references at the end of this chapter). A number of )proaches to combinatorial chemistry exist. These include the split-mix method, serial techniques and parallel methods to generate libraries of compounds. The advances in combinatorial chemistry are also accompani by sophisticated methods in deconvolution and identification of compounds from libraries. In a number of cases, innovative hardware and software has been developed tor these purposes. [Pg.75]

These conceptual goals are attained by several combinatorial methods and tools. Characteristic for combinatorial chemistry is the synthesis on solid support or by polymer-supported synthesis, allowing for much higher efficiency in library production. Synthesis can be conducted either in automated parallel synthesis or by split-and-recombine synthesis. Centerpieces of combinatorial methods further include specific analytical methods for combinatorial... [Pg.381]

Introduced in the early 1990s, the split-and-recombine concept contributed much to the early success of combinatorial chemistry. Often, all combinatorial methods were identified with this concept. Split-and-recombine synthesis offered easy access to large number of individual compounds in few steps. If conducted on polymer beads, these are easily separated mechanically and can be identified subsequent to a screening step. [Pg.383]

Combinatorial Chemistry. Figure 2 Chemical libraries are prepared either by parallel synthesis or by the split-and-recombine method. In the latter case, coupling m building blocks in m separated reaction flasks through n synthetic cycles on a beaded polymer carrier generates a combinatorial library with nf individual compounds and one compound per bead. [Pg.383]

There are two basic combinatorial chemistry techniques (1) parallel synthesis and (2) split and mix methods. They are illustrated next. [Pg.73]

Outline a design for a combinatorial synthesis for the formation of a combinatorial library of nine compounds with the general formula B using the Furka mix and split method. Outline any essential practical details. Details of the chemistry of peptide link formation are not required it is sufficient to say that it is formed. [Pg.130]

Much of the early work in combinatorial chemistry focused on the preparation of large mixtures of compounds. The most widely used technique for mixture synthesis is the split/recombine method which assures that each component of the mixture is present in approximately equimolar concentrations. The structures of the bound ligands are determined either through an iterative, or reclusive, deconvolution strategy or through the use of encoded libraries. [Pg.3]

Combinatorial chemistry is the production of libraries of compounds that represent permutations of a set of chemical variables. These variables include the nature of the substituent in a particular molecule, both in type and size, changes in the components in a mixture of materials, e.g. in ceramics and changes in process parameters, e.g. temperature, pH etc. Chemical libraries are usually created by one of two methods split and mix or parallel synthesis . Split and mix synthesis is used to produce small quantities of a relatively large number of compounds and requires assays to be performed on pools of compounds. Parallel synthesis is used to produce libraries... [Pg.105]

Furka A, Combinatorial chemistry from split-mix to discrete, in Combinatorial Chemistry and Combinatorial Technologies Methods and Applications (Eds. Fassina G, Miertus S), pp. 7-32, 2005, chapter 3, this volume. [Pg.139]

This rapid molecular formula determination may also be applied to complex mixtures such as those which arise from combinatorial chemistry.To demonstrate the performance of this method in this respect, a split-mix compound collection of 140 different pyrrole amides consisting of 10 subcollections of 14 compounds each was synthesized on Rink-amide-AM-resin. [Pg.570]

At the other end of the scale, products can be isolated on single beads of resin produced by combinatorial chemistry, involving sequential splitting and mixing batches of beads between reaction steps such that single beads contain only one product. Spectroscopic methods have been developed for the non-destructive characterisation of products while still on the bead. ... [Pg.100]


See other pages where Combinatorial chemistry split method is mentioned: [Pg.552]    [Pg.384]    [Pg.208]    [Pg.65]    [Pg.69]    [Pg.89]    [Pg.235]    [Pg.170]    [Pg.436]    [Pg.19]    [Pg.530]    [Pg.290]    [Pg.337]    [Pg.384]    [Pg.301]    [Pg.117]    [Pg.164]    [Pg.542]    [Pg.376]    [Pg.126]    [Pg.23]    [Pg.29]    [Pg.101]    [Pg.133]    [Pg.197]    [Pg.234]    [Pg.1013]    [Pg.362]    [Pg.151]    [Pg.83]    [Pg.1]    [Pg.4]    [Pg.280]   
See also in sourсe #XX -- [ Pg.898 ]




SEARCH



Combinatorial Chemistry

Combinatorial methods

© 2024 chempedia.info