Combinatorial chemistry methodology

Computational and combinatorial chemistry methodology helped to create a highly selective phenothiazine derivative which can serve as a novel lead compound for further development in the field of COX-2 inhibitors (Dannhardt and Kiefer, 2001). 

Products/technologies The company tailors its combinatorial chemistry methodologies to meet specific client needs. It offers three main levels of products and services, which include a fully integrated lead discovery, expansion, and optimization service design and synthesis of high-purity, diverse or focused representational arrays and supply of custom-designed combinatorial synthesis sets. 

To develop the melt-polymerization polymers using a combinatorial chemistry methodology,it is critical to find the optimal process parameters. Unlike the traditional melt-polymerization scheme which involves stirring the reaction components in a vacuum, " the combinatorial approach is based on thin-film melt-polymerization at atmospheric pressure and without stirring. ... 

Specific peptides have become one of the most common sources of active ingredients in cosmetics. To synthesize peptides today, combinatorial chemistry methodologies (Nielsen, 2(X)2) are employed making it possible to use different processes to rapidly and simultaneously synthesize a large number of compounds (combinatorial libraries) and subsequently to determine their potential usefulness. This working method is more and more commonly used in the pharmaceutical industry, since it makes it possible to identify and isolate active molecules rapidly. 

The feasibility of multistep natural product total synthesis via solid-phase methodology, and its application to combinatorial chemistry, was first demonstrated by Nicolaou and coworkers in epothilone synthesis and in the generation of an epothilone library [152]. The traceless release of TBS-protected epoC 361 by RCM of resin-bound precursor 360 (Scheme 69) is an early and most prominent example for the strategy outlined in Fig. 11a. 

In addition, further automation will be needed in what is still very much a hands-on art. Autoinjectors coupled to complete analytical data systems and readers for 96-well plates are the beginning of what will continue to be a necessary trend of residue chemistry. The application of the techniques of combinatorial chemistry/biochemistry, which has produced screening methodology for handling many variables, might be appropriate to residue chemistry. 

Abstract In this chapter different types of domino-processes are described which consist of the combination of cationic, anionic, radical, pericyclic and transition metal-catalyzed as well other reactions. The methodology is used for the highly effective synthesis of carbocycles and heterocycles as well as of natural products and other interesting materials. It is also employed as an efficient tool in combinatorial chemistry. 

Combinatorial chemistry, 7 380-434 8 400—401 13 283-284. See also High-throughput experimentation applications, 7 381-383 commercial environment, 7 387-389 methodology, 7 383-387 microwaves in, 16 548-552 nomenclature, 7 380 polymers, 7 405—413 Combinatorial libraries, 12 515-517 Combinatorial methods, 7 380 Combinatorial optimization approach, in computer-aided molecular design, 26 1037... 

The feasibility of multi-step natural product total synthesis via solid-phase methodology, and its application to combinatorial chemistry, was first achieved by Nicolaou and co-workers in epothilone synthesis and in the synthesis... 

As combinatorial chemistry has been fully integrated into the modern drug discovery process, more computational search methodologies against large virtual combinatorial compound spaces have been steadily developed in recent years (11-16). A detailed summary and comparison of those published methods are reported in the Section 5 and in Table 13.6. A good review on this subject could also be found in the publication by Boehm and coworkers (16). 

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