Combinatorial chemistry organic synthesis methodologies

Perhaps the most important issues to consider now are the application of novel methodologies, molecular diversity, and synthetic convenience. There have been several reports of novel, one-pot procedures for the preparation of 1,2,4-triazoles with diverse structures. Synthesis of 1,2,4-triazoles on polymeric supports, in both solution and solid phase, represents a step toward the combinatorial synthesis of these heterocycles. It is these novel applications of technology to organic synthesis that perhaps lead the way in 1,2,4-triazole chemistry. 

Despite the noteworthy developments in new synthetic methodologies during the last ten years (achieved in catalysis, asymmetric synthesis, combinatorial chemistry, and other fields), organic synthesis is generally still being carried out... 

There is an enormous wealth of diverse methodologies and methods at our disposal to comprehend and to manage the concept of combinatorial chemistry. In this article however, we wish to focus our discussion on molecules synthesized by organic synthesis. The majority of combinatorial compounds hitherto produced have been synthesized on solid support, either as collections of single compounds or as libraries. The choice between these strategies varies from case to case and depends on individual preferences. In gener-... 

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