High-energy collision dissociation

Nizigiyimana, L. Rajan, P.K. Haemers, A. Claeys, M. Derrick, P.J. Mechanistic Aspects of High-Energy Collision-Induced Dissociation Proximate to the Charge in Saturated Fatty Acid n-Butyl Esters Ca-tionized With Lithium. Evidence for Hydrogen Radical Removal. Rapid Commun. Mass Spectrom. 1997, 11, 1808-1812. 

Griffiths WJ, Alvelius G, Liu S, Sjovall J (2004) High-energy collision-induced dissociation of oxosteroids derivatised to Girard hydrazones. Eur J Mass Spectrom (Chichester, Eng) 10 63-88... 

Yates, J.R., Eng, J.K., Clauser, K.R. and Burlingame, A.L. (1996) Search of sequence databases with uninterpreted high-energy collision-induced dissociation spectra of peptides. J. Am. Soc. Mass Spectrom., 7 (11) 1089-98. 

Nizigiyimana, L., Van Den Heuvel, H. and Claeys, M. (1997) Comparison of low- and high-energy collision-induced dissociation tandem mass spectrometry in the analysis of ricinoleic and ricinelaidic acid. J. Mass Spectrom., 32 (3), 277-86. 

It must be mentioned that Ricehas postulated a different mechanism for the dissociation of a diatomic molecule. He assumes that only ordinary thermal collisions of molecules excited into extremely high vibrational states are responsible for the dissociation. The effect of the rotation is then only to increase the density of these excited states. We4 instead believe that the probability of the high-energy collisions and of the excited rotational states is comparable with that of the high vibrational excited states, and that all these probabilities must be added with the proper weight. 

In the chain reaction producing NO, the initiation step is the dissociation of O2, which requires a high-energy collision between O2 and another molecule M (it could be O2 or N2) ... 

Once the exact mass is determined for the precursor ion, the instrument is switched to tandem MS mode (TOF/TOF mode) and fragment ions are generated using laser-induced dissociation (LID) and/or high energy collision-induced dissociation (CID) (13) (see Note 12). 

Macht, M., Asperger, A., and Deininger, S. O. (2004) Comparison of laser-induced dissociation and high-energy collision-induced dissociation using matrix-assisted laser desorption/ionization tandem time-of-flight (MALDI-TOE/TOF) for peptide and protein identification. Rapid Commun. Mass Spectrom. 18, 2093-2105. 

The main advantage of the FAB technique compared to ESI and MALDI is, in fact, not the ionization method itself but the type of mass analyzer it works with. FAB ion sources are usually attached to magnetic sector, double-focusing mass spectrometers, enabling accurate mass measurements and, which is even more important, allowing the study of high-energy collision-induced dissociation (CID) reactions which provide information about the structure of the studied ion (see next section). 

Bottrill, A. R., Giannakopulos, A. E., Waterson, C., Haddleton, D. M., Lee, K. S., and Derrick, P. J., Determination of End-Groups of Synthetic Polymers by Matrix-Assisted Laser Desorption/Ionization High-Energy Collision-Induced Dissociation, Anal. Chem., 71, 3637,1999. 

K. F. Medzihradszky, B. L. Gillece-Castro, R. R. Townsend, A. L. Burlingame, and M. R. Hardy, Structural elucidation of O-linked glycopeptides by high energy collision-indnced dissociation, J. Am. Soc. Mass Spectrom. 7, 319-328 (1996). 

B. Kilster, T. J. P. Naven, and D. J. Harvey, Effect of the reducing-terminal substituents on the high energy collision-induced dissociation matrix-assisted laser desorption/ionization mass spectra of oligosaccharides. Rapid Commun. Mass Spectrom. 10, 1645-1651 (1996). 

Biemann, K. (1990) Sequencing of peptides by tandem mass spectrometry and high-energy collision-induced dissociation. Methods Enzymol., 193, 455-479. 

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