Collagen degeneration

Grenz zone prominent, elastogenesis, elastosis, collagen degeneration, loss of anchoring fibrils... 

Fig. 15.2. a Biopsy of a 50-year-old Caucasian woman showing epidermal atrophy and collagen degeneration, b Biopsy of a 50-year-old African American woman showing minimal to no evidence of photodamage... 

Grenz zone prominent, elastogenesis, elastosis, collagen degeneration, loss of anchoring fibrils Microvasculature abnormal Blood vessels dilated, twisted later stages - sparse, perivenular lymphohistiocytic infiltrates... 

Renal effects have been observed in both male and female rats in a chronic-duration oral study. Male Fischer 344 rats exposed to 1,4-dichlorobenzene at 150 and 300 mg/kg/day for 2 years exhibited nephropathy, epithelial hyperplasia of the renal pelvis, mineralization of the collecting tubules in the renal medulla, and focal hyperplasia of the tubular epithelium. Each of these effects was associated with hyalin droplet formation. There were also increased incidences of nephropathy in female Fischer 344 rats dosed with 1,4-dichlorobenzene at 300 and 600 mg/kg/day. Histopathologically, the nephropathy was characterized by degeneration and regeneration of the tubular epithelium, tubular dilatation with attenuation and atrophy of the epithelium, granular casts in the tubules of the outer stripe of the medulla, thickening of the basement membranes, and minimal accumulation of interstitial collagen (NTP 1987). 

In mice dosed at 300 and 600 mg/kg/day, there was also an increased incidence of nephropathy (consisting primarily of degeneration of the cortical tubular epithelium with thickening of the tubular and glomerular basement membranes and increased interstitial collagen in male mice, and renal tubular regeneration in female mice). 

Maroudas, A. (1976) Balance between swelling pressure and collagen tension in normal and degenerate cartilage. Nature 260, 808-809... 

Some investigations have been made with the object of determining a possible role for hyaluronate in rheumatoid arthritis. This disease is characterized by fibrinoid degeneration, collagen decomposition, and lesions. It has been suggested that changes in either the concentration or the structure... 

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