Collaborative Study on the Genetics

The Collaborative Study on the Genetics of Alcoholism (COGA) is a large, multi-center, family-based study of the general U.S. population Approximately 11,000 people have been interviewed and extensively characterized, and genomic... 

Xu, J. F., Meyers, D. A., Ober, C., et al. (2001) Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations collaborative study on the genetics of asthma. Am. J. Hum. Genet. 68, 1437-1446. 

Collaborative Study on the Genetics of Asthma A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997 15 389-392. (Ill)... 

Biemt LJ, Saccone NL, Rice JP, et al. Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism. Alcohol Res Health 2002 26 208-213. 

Daeppen JB, Smith TL, Danko GP, Gordon L, Landi NA, Numberger JI Jr, et al (2000) Clinical correlates of cigarette smoking and nicotine dependence in alcohol-dependent men and women. The Collaborative Study Group on the Genetics of Alcoholism. Alcohol Alcohol 35(2) 171-175... 

Liber, H.L. (1985) Mutation tests with Salmonella using 8-azaguaiune resistance as the genetic marker. In Ashby, J., de Serres, F.J., Draper, M., Ishidate, M., Jr, Margolin, B.H., Matter, B.E. Shelby, M.D., eds. Progress in Mutation Research, Volume 5, Evaluation of Short-Term Tests for Carcinogens. Report of the International Programme on Chemical Safety s Collaborative Study on in vitro Assays, Amsterdam, Elsevier Science, pp. 213-216... 

A large proportion of the genetic toxicity data on y-butyrolactone is derived from a collaborative study involving up to seventeen laboratories. 

J.Norris and collaborators showed that also acid ceramidase activity in cells vanishes following treatment with desipramine (Elojeimy et ah, 2006) thus, the compound depletes lysosomes of both a ceramide generating and consuming enzyme (and few authors have studies the net effect on cellular ceramide levels when using such inhibitors). Therefore, the many studies in the literature using this class of ASMase inhibitors have to be taken with caution firm conclusions can only be reached when effects seen with these compounds are backed up by experiments with genetically ASMase deficient cells or cells depleted for ASMase by using siRNA. 

To assess the relationship of Hey concentrations with vascular disease risk, a meta-analysis of observational studies was carried out, showing that elevated Hey is at most a modest independent predictor of ischemic heart disease and stroke risk in healthy populations. Studies of the impact on disease risk of genetic variants that affect blood Hey concentrations will help determine whether Hey is causally related to vascular disease, as may large randomized trials of the effects on ischemic heart disease and stroke of vitamin supplementation to lower blood Hey concentrations (Homocysteine Studies Collaboration 2002). 

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