Colistin Vancomycin

TEICOPLANIN ANTIBIOTICS - AMINOGLYCOSIDES, COLISTIN, VANCOMYCIN t risk of nephrotoxicity and ototoxicity Additive effect Hearing and renal function should be carefully monitored... 

AMPHOTERICIN ANTIBIOTICS -AMINOGLYCOSIDES, COLISTIN, VANCOMYCIN Risk of renal failure Additive effect Monitor renal function closely... 

PLATINUM COMPOUNDS AMINOGLYCOSIDES, CAPREOMYCIN, COLISTIN, STREPTOMYCIN, VANCOMYCIN t risk of renal toxicity and renal failure and of ototoxicity. The ototoxicity tends to occur when cisplatin is administered early during the course of aminoglycoside therapy Additive renal toxicity Monitor renal function prior to and during therapy, and ensure an intake of at least 2 L of fluid daily. Monitor serum potassium and magnesium and correct any deficiencies. Most side-effects of aminoglycosides are dose-related, and it is necessary to t interval between doses and 1 dose of aminoglycoside if there is impaired renal function... 

Clinically important, potentially hazardous interactions with amikacin, cephaloridine, colistin, gentamicin, kanamycin, neomycin, streptomycin, tobramycin, vancomycin... 

Sulfonamides Choramphenicol Rifampin Ethionamide Metronidazole Therapeutic Levels Penicillin G Carbenicillin Nafcillin Piperacillin Cefotaxime Ceftriaxone Imipenem Meropenem Vancomycin Vidarabine Flucytosine Pyrimethamine Acyclovir Linezolid Colistin... 

Polypeptides Bacitracin, Colistimethate sodium, Colistin, Polymyxin B, Tekoplanin, Vancomycin... 

Vancomycin is both potentially nephrotoxic and ototoxic, and its manufacturers therefore suggest that it should be used with particular care, or avoided in patients with renal impairment or deafiiess. They also advise the avoidance of other drugs that have nephrotoxic potential, because the effects could be additive. They list amphotericin B, aminoglycosides, bacitracin, colistin, poymyxin B, viomycin and cisplatin. They also list etacrynic acid and furosemide as potentially aggravating ototoxicity. 

In a retrospective case-control study of 134 patients who received 139 courses of intravenous colistin for at least 24 hours the cumulative incidence of nephrotoxicity was 73/139 (52%) [108. Independent susceptibility factors were old age, prolonged duration of intravenous cohstin, and concomitant vancomycin therapy. 

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