Clinical phenotypes genetic variation

The genetic variability demonstrated by BuChE leads to a wide spectrum of in vivo activity with respect to its main pharmacological substrates, which can have severe clinical consequences. The same variability also produces differences in the degree of inhibition by a range of different substances, which allows biochemical characterization (phenotyping) to be performed. Recently, it has also been shown that genetic variation in AChE occurs, which may account for differences in responses to the therapeutic use of anticholinesterases. 

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