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Clinical considerations

This chapter has covered the topic of pharmaceutical colloids, with a special emphasis on emulsions and suspensions. These have been rather traditional pharmaceutical forms, but they are attracting increasing interest because of increased knowledge of the biodistribution and fate of colloidal particles in the body, and the need to deliver highly lipophilic and often very potent dmgs in carriers. Emulsions, microemulsions and solid suspensions are all, therefore, important in modern dmg delivery. [Pg.271]

The chapter has dealt with the stability and stabilisation of colloidal systems and covered topics such as their formation and aggregation. If the particle size of a colloidal particle determines its properties (such as viscosity or fate in the body), then maintenance of that particle size throughout the lifetime of the product is important. The emphasis in the section on stability is understandable. Various forms of emulsions, microemulsions and multiple emulsions have also been discussed, while other chapters deal with other important colloidal systems, such as protein and polymer micro- and nanospheres and phospholipid and surfactant vesicles. [Pg.271]

Towards the end of the chapter we point out the biological importance of an understanding of colloid chemistry and several examples of biological importance are covered. Pharmaceutical and biological colloids are often very [Pg.271]

Chapter 7 Emulsions, suspensions and other disperse systems [Pg.272]

Florence and D. Whitehill. Some features of breakdown in water-in-oil-in-water multiple emulsions. /. Colloid Interface Sci., 79, 243-56 (1981) [Pg.272]


Another clinical consideration is the abiUty of local anesthetic agents to effect differential blockade of sensory and motor fibers. In surgical procedures such as obstetrics or postoperative pain rehef, an agent which produces profound sensory block accompanied by minimal motor block is desirable. On the other hand some procedures such as limb surgery require both deep sensory and motor blockade. In clinical practice, bupivacaine ( 22,... [Pg.414]

Mount, G. J. (1984). Glass ionomer cements clinical considerations. In Clarke, J. W. (ed.) Clinical Dentistry, Chapter 20A. Philadelphia Harper Row. [Pg.187]

VIII. CLINICAL CONSIDERATIONS IN PARENTERAL PRODUCT DESIGN... [Pg.410]

This chapter on prescriber incentives brings together various midpoints, all of them difficult to find. One of these midpoints concerns incentives (if there is one distinguishing feature of health care organizations it is the advisability of moderating the power of incentives in order to stop financial considerations from short-circuiting clinical considerations) another concerns the balance between health policy issues and industrial policy ones and a third concerns the influences exerted on prescription by the market, the state and clinical standards (the combination of financial and non-financial incentives). [Pg.183]

Kellermeyer, R.W., A.R.Tarlov, G.J.Brewer, P.E.Carson, and A.S.Alving. 1962. Hemolytic effect of therapeutic Drugs Clinical considerations of the primaquine-type hemolysis. JAMA 180 388-394. [Pg.116]

Miller, L.G., Herbal medicinals Selected clinical considerations focusing on known or potential drug-herb interactions, Arch Intern Med, 158, 2200, 1998. [Pg.203]

Jordan VC. Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents. JMed Chem 2003 46 1081-100. [Pg.78]

The muscarinic cholinergic receptor is competitively blocked by hyoscine and hyoscyamine. Both of these alkaloids are more active than atropine. The applications of these alkaloids for clinical purposes are connected with the induction of general anaesthesia. Clinical consideration should be paid to the fact that these alkaloids also affect the brain and thereby the central nervous system. Atropine crosses the blood-brain barrier. Hyoscine and hyoscyamine depress the motor areas of the cerebral cortex. [Pg.185]

WUliams DM. Clinical considerations in the use of inhaled corticosteroids for asthma. Pharmacotherapy 2001 21 38S 8S. [Pg.468]

Wodak A, Seivewright NA, Wells B, Reuter P, Des Jarlais DC, Rezza G et al. (1994). Comments on Ball van de Wijngaart s A Dutch addict s view on methadone maintenance - an American and a Dutch appraisal . Addiction, 89, 803-14 Wolff K (2002). Characterization of methadone overdose clinical considerations and the scientific evidence. Theraputic Drug Monitoring, 24, 457-70... [Pg.174]

Mei QB, Tao JY, Cui B. Advances in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese dang gui). Chin Med J 1991 104 776-781. Mashour NH, Lin GI, Frishman WH. Herbal medicines for the treatment of cardiovascular disease clinical considerations. Arch Intern Med 1998 158 2225-2234. [Pg.144]

Chu LF, Angst MS, Clark D Opioid-induced hyperalgesia in humans Molecular mechanisms and clinical considerations. [Pg.709]

The search for selective means of inactivation, prompted by clinical considerations, has not been successful, although many substrate analogs act as powerful competitive inhibitors 8). On the other hand, irreversible inhibition may result from interaction with substrate analogs which cause labilization of the enzyme (see Section IV,B). Specific stimulation and inhibition by homologous antibodies is reviewed in Section V. [Pg.43]

Gilbertson EO, Spellman MC, Piacquadio DJ, Mulford MI. Super potent topical corticosteroid use associated with adrenal suppression clinical considerations. J Am Acad Dermatol 1998 38(2 Part 2) 318-21. [Pg.67]

Sulfonylurea drugs basic and clinical considerations. Sydney, Australia, 20 November 1988Proceedings. Diabetes Care 1990 13(Suppl 3) l-58. [Pg.454]

Although unfractionated heparin (UFH) has long been used as the standard anticoagulant with great potency there are some therapeutic dilemmas in its use. Given the availability of new anticoagulants and to address these clinical considerations, the choice of the anticoagulant should take into account the individual patient s condition. [Pg.93]

Buckley NA, Faunce TA. Atypical antidepressants in overdose. Clinical considerations with respect to safety. Drug Saf 2003 26 539-51. [Pg.5]

Rossiter A, Souney PF. Interaction between MAOIs and opioids pharmacologic and clinical considerations. Hosp Formul 1993 28(8) 692-8. [Pg.86]

Sidell, F.R. 1992. Clinical considerations in nerve agent intoxication. In Chemical Warfare Agents, S. Somani, ed., Academic Press, N.Y., pp 155-194. [Pg.142]

Einally, pharmacokinetics in the efficacy/safety trial population are essentially similar to pharmacokinetics in healthy subjects, and no patient-specific factor warranting clinical consideration of dose regimen adjustment was identified in these analyses [65]. [Pg.327]


See other pages where Clinical considerations is mentioned: [Pg.95]    [Pg.39]    [Pg.208]    [Pg.284]    [Pg.246]    [Pg.117]    [Pg.53]    [Pg.351]    [Pg.247]    [Pg.505]    [Pg.239]    [Pg.608]    [Pg.645]    [Pg.161]    [Pg.172]    [Pg.87]    [Pg.10]    [Pg.332]    [Pg.7]    [Pg.67]   


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