Clinical chemical study

Svendsen C K, Hjortkjaer R K, Hesselholt M 1979 Colic in the horse. A clinical and clinical chemical study of 42 cases. Nordisk Veterinaermedicin 31(Suppl) 1-32 Swanson J T, Aldrete J A 1989 Thrombophlebitis after intravenous infusion. Factors affecting its incidence. Rocky Mountain Medical Journal 66 48-51 Tasker J B 1967 Fluid and electrolyte studies in the horse III. Intake and output of water, sodium and potassium in normal horses. Cornell Veterinarian 57 649- 57 Taylor P 1996 Heat stroke, exhaustion and synchronous diaphragmatic flutter (SDF). In Dyson S (ed) A guide to the management of emergencies at equine competitions. Equine Veterinary Journal (A British Equine Veterinary Association Manual), Newmarket, UK, pp. 102-113... 

Extensive biotransformation studies have been conducted with the As-pidosperma alkaloid vindoline, but much less work has been done with monomeric Iboga and dimeric alkaloids from this plant. The long-standing interest in this group of compounds stems from the clinical importance of the dimeric alkaloids vincristine and vinblastine, both of which have been used for more than 2 decades in the treatment of cancer. Few mammalian metabolites of dimeric Catharanthus alkaloids have been characterized. Thus the potential role of alkaloid metabolism in mechanism of action or dose-limiting toxicities remains unknown. The fact that little information existed about the metabolic fate of representative Aspidosperma and Iboga alkaloids and Vinca dimers prompted detailed microbial, mammalian enzymatic, and chemical studies with such compounds as vindoline, cleavamine, catharanthine, and their derivatives. Patterns of metabolism observed with the monomeric alkaloids would be expected to occur with the dimeric compounds. 

Clinical Laboratory. Clinical chemical and hematological parameters for minipigs have been studied. Ranges for some of the more commonly examined parameters from Yucatan minipigs are summarized in Tables 16.9 and 16.10 (from Radin, Weiser and Frettman, 1986). Parson and Wells (1986) have published similar data on the Yucatan minipig. Brechbuler, Kaeslin and Wyler (1984), Oldigs (1986),... 

Klee G, Bertino JR, Sim VM Clinical psychiatric studies of subjects receiving EA 1729. Chemical Warfare Laboratory Report 2159. August 1957. 

Laws ER Jr, Curley A, Biros FJ Men with intensive occupational exposure to DDT—a clinical and chemical study. Arch Environ Health 15 766-755, 1967... 

Hansen, A. E., Wiese, H. F., Boelsche, A. N., Haggard, M. E., Adam, D.J.D. and Davis, H. 1963. Role of linoleic acid in infant nutrition. Clinical and chemical study of 428 infants fed on milk mixtures varying in kind and amount of fat. Pediatrics 31, 171 — 192. 

Any company or institution performing non-clinical safety studies for the submission of data for a new chemical entity a new biological, immunological, pesticide, veterinary or agrochemical product or, for that matter, a similar product that will eventually appear in the marketplace and be consumed by the general public must adhere to GLP in the conduct of their non-clinical safety study experimentation. 

Clinical safety studies are conducted in human volunteers to determine the safety of chemicals, drugs, formulations, devices, or other products, which may come in contact with the human body. Clinical safety testing should always be conducted prior to efficacy investigations in order to determine the benefit/risk ratio of efficacy trials. When designing a study, benefits and risks shall be balanced and shown to be in a favorable ratio (The Belmont Report). The rights, safety and well-being of the trial subjects are the most important considerations. (ICH Guidelines 2.3). 

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