Gentamicin Clindamycin

Noninterfering acyclovir, amikacin, amphotericin B, cefazolin, ceftazidime, clindamycin, gentamicin, metronidazole, piperacillin, trimethoprim, sulfamethoxazole... 

Butiois DE, de Torrente A, Term an DS. Renal failure followii gentamicin in combination with clindamycin Gentamicin nephrotoxicity. pferow(1976) 17,307-13. 

There appear to be no clinically significant pharmacokinetic interactions between aztreonam and amikacin, cefradine, clindamycin, gentamicin, metronidazole or nafcillin. 

Clindamycin and metronidazole appear to be equivalent in efficacy when combined with agents effective against aerobic gram-negative bacilli (e.g., gentamicin or aztreonam). 

Pelvic Inflammatory Disease Cefotetan or cefoxitin with doxycycline 1. Clindamycin with gentamicin 2. Ampicillin-sulbactam with doxycycline 3. Ciprofloxacin with doxycycline and metronidazole... 

Clindamycin 900 mg IV every 8 hours and gentamicin, loading dose IV or IM (2 mg/kg) followed by maintenance dose (1.5 mg/kg) every 8 hours (a single daily dose may be used)... 

The answer is e. (Hardman, pp 1092-10945 Cefoxitin and cefmeta-zole are suitable for treating intraabdominal infections. Such infections are caused by mixtures of aerobic and anaerobic Gram-negative bacteria like B. fragilis. Cefoxitin alone has been shown to be as effective as the traditional therapy of clindamycin plus gentamicin. 

FCC,b c trimethoprim-sulfamethoxazole, clindamycin ampidllin-sulbadam, or amoxidllinresistant Vancomycin (gentamicin or rifampin)... 

Pelvic inflammatory Cefotetan or cefoxitin with doxycy- 1. Clindamycin with gentamicin... 

Head and neck cancer resection Cardiothoracic surgery 5. aureus, streptococci oral anaerobes Clindamycin 600 mg at induction and every 8 hours x 2 more doses Add gentamicin for clean-contaminated procedures IA... 

Gentamicin- An alternative regimen for pelvic inflammatory disease is gentamicin plus clindamycin. Continue for at least 4 days and at least 48 hours after patient improves then continue clindamycin 450 mg orally 4 times daily for 10 to 14 days total therapy. 

Acute salpingitis (pelvic inflammatory disease) due to Neisseria gonorrhoeae. Chlamydia trachomatis, or both is often complicated by superinfection with gramnegative bacilli and anaerobes. A combination of gentamicin, clindamycin, and doxycycline has been shown to be an effective treatment for this polymicrobial infection. 

Gentamicin (Garamycin) Erythromycin estolate (llosone) Doxycycline (Monodox, Vibramycin, others) Clindamycin (Cleocin)... 

Staphylococcus aureus Abscesses bacteremia cellulitis endocarditis osteomyelitis pneumonia others If methicillin-sensitive nafcillin or oxacillin If methicillin-resistant vancomycin gentamicin or rifampin 1 st-generation cephalosporin clindamycin erythromycin trimethoprim-sulfamethoxazole a penicillin + a penicillinase inhibitor... 

Coverage by a combination of antibiotics such as, clindamycin plus gentamicin, effective against gram-positive, gramnegative and anaerobes, or... 

Clindamycin (to cover staphylococci, streptococci and anaerobes) plus gentamicin, ciprofloxacin, ceftazidime or aztreonam (to cover Gram-negative organisms including Pseudomonas). 

Special risk patients, i.e. with prosthetic valves or with previous endocarditis, should receive amoxicillin 1 g i.m. or i.v. and gentamicin 120 mg at induction, then amoxicillin 0.5 g by mouth 6 h later. Patients who are penicillin-allergic or have received penicillin more that once in the previous month should receive vancomycin 1 g i.v. over 100 min then gentamicin 120 mg i.v. at induction or 15 min before the procedure or teicoplanin 400 mg i.v. plus gentamicin 120 mg i.v, at induction or 15 min before the procedure or clindamycin 300 mg over at least 10 min at induction or 15 min before the procedure then clindamycin 150 mg i.v. or by mouth 6 h later. 

Head and neck S. aureus, streptococci oral anaerobes Cefazolin 2 g or clindamycin 600 mg at induction and q8h x 2 more doses Addition of gentamicin to clindiamycin is controversial... 

Answer A. Clindamycin has a mechanism of action similar to, if not identical with, erythromycin and related macrolides. They bind to rRNA bases on the 50S subunit to prevent translocation of peptidyl-mRNA from the acceptor to the donor site. Chloramphenicol also binds to the 50S subunit but interferes with the activity of pep-tidyltransferase. Gentamicin and tetracyclines bind to the 30S ribosomal subunit. Imipenem is a cell-wall synthesis inhibitor, acting similarly to beta-lactams. 

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