Cisplatin-derivatives

Inorganic and Organometallic Chemistry of Cisplatin-Derived Diplatinum(III) Complexes... 

Briz, O., Serrano, M.A., Rebollo, N., Hagenbuch, B., Meier, P.J., Koepsell, H. and Marin, J.J. (2002) Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum (II) toward liver cells. Molecular Pharmacology, 61, 853-860. 

Since the discovery by Rosenberg [88] that cisplatin is an effective anticancer drug, large synthesis and evaluation programs have aimed at the creation of cisplatin derivatives that show greater and more wide-spread activity against cancer but with... 

Malik, Duncan, Tomalia, and Esfand [29] reported the use of a variety of amine and acid-containing polymers that chelated platinum forming cisplatin derivatives. They also reported the synthesis of similar dendritic-antineoplastic drugs using vanadocene dichloride. The structure from the poly(propyleneimine) dendrimers contains units are shown in (5) and (6). 

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