Olanzapine ciprofloxacin

Ciprofloxacin Olanzapine Ciprofloxacin inhibits CYP1A2. As a result the plasma-concentration of olanzapine increases... 

Olanzapine 1A2 2D6 Fluvoxamine, ciprofloxacin, paroxetine Cigarette smoking... 

Betamethasone + Gentamicin S-Amlodipine + Losartan S-Amlodipine + Atenolol Pioglitazone + Glimeperide Glimeperide + Metformin Rosiglitazone + Glimeperide Tramadol + Paracetamol Ramipril + s(-) Amlodipine Olanzapine + Fluoxetine Ciprofloxacin + Ornidazole Quinapril + HCTZ (Hydrochlorothiazide)... 

The plasma concentration of olanzapine doubled in a patient who also took ciprofloxacin, a potent inhibitor of CYP1A2 (270). The magnitude of the interaction was surprising, because available data suggest that CYP1A2-mediated oxidation of olanzapine accounts for only a small portion of the biotransformation of olanzapine relative to glucuronidation. 

Markowitz JS, DeVane CL. Suspected ciprofloxacin inhibition of olanzapine resulting in increased plasma concentration. J Clin Psychopharmacol 1999 19(3) 289—91. 

CLOZAPINE, OLANZAPINE CIPROFLOXACIN t clozapine levels and possibly t olanzapine levels Ciprofloxacin inhibits CYP1A2 clozapine is primarily metabolized by CYP1A2, while olanzapine is partly metabolized by it Watch for the early features of toxicity to these antipsychotics. A1 in dose of clozapine and olanzapine may be required... 

Based on current information, inhibitors of CYP 1A2 have the greatest potential for causing interactions with olanzapine. Examples include cimetidine, fluvoxamine, and fluoroquinolone antibiotics (e.g., ciprofloxacin) to varying degrees. To date, however, no serious inhibition interactions have been reported with olanzapine, which may be a result of olanzapine s wide therapeutic index. Carbamazepine has been reported to increase olanzapine elimination by as much as 50%. Cigarette smoking is a potent inducer of CYP 1A2, and one would expect lower mean olanzapine serum concentrations in smokers compared to nonsmokers. 

CYP1A2 15 -5 Fluvoxamine Caffeine Cyclobenzaprine Theophylline Thiothixene Olanzapine Ciprofloxacin Fluvoxamine Ticlopidine Halogenated biphenyls Polycyclic aromatic Hydrocarbons Omeprazole Rosiglitazone Phenylisothiocyanate... 

Anecdotal data suggest that low doses (250 mg twice daily) of ciprofloxacin, a potent inhibitor of CYP1A2, result in a moderate elevation (about 30%) of clozapine plasma levels. There are anecdotal data suggesting that the addition of ciprofloxacin 250 mg twice daily almost doubles the plasma concentration of olanzapine. 

The olanzapine levels of a patient were reduced when ciprofloxacin was stopped. 

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