Cinobac - Cinoxacin

Examples of urinary anti-infectives include cinoxacin (Cinobac), fosfomycin (Monurol), metlienamine rnande-late (Mandelamine), nalidixic acid (NegGram), and nitrofurantoin (Puradantin). 

Cinoxacin, U5P. l-E(hyl-l.4-dihydro-4-oxo l.3 d>ov ulo 4,Sg]cinnoline-3-carboxylic acid (Cinobac) is a close congener (isostcre) of oxolinic acid (no longer marketed in (he United States) and has antibacterial propenies similar to (hose of nalidixie and oxolinic acid.s. 

The quinolones include nalidixic acid (NegGram), cinoxacin (Cinobac), norfloxacin (Noroxin), and ciprofloxacin (Cipro). Other members of the quinolone family are pefloxacin, ofloxacin, enoxacin, and fleroxacin. The bacterial enzyme DNA gyrase is responsible for the continuous introduction of negative supercoils into DNA, and the quinolones inhibit this gyrase-mediated DNA supercoiliiig. 

Ofloxacin (Floxin) Cinoxacin (Cinobac Pulvules) Temafioxacin (Omniflox) Lomefioxacin (Maxaquin) a 1 u n PO. (Pharmacokinetic comparisons will be made in the next printing, when more information is available.)... 

Cinoxacin (Cinobac) is a synthetic organic antibacterial compound reported to show antibacterial activity against Gram-negative rods responsible for urinary tract infection. Israel et al. (1978) reported the serum concentrations in Table P1.2 following intravenous bolus administration of 50 and 100 mg of cinoxacin to healthy male voltmteers. 

In this question, plasma concentration versus time data is provided following the administration of two different doses of a drug (cinoxacin Cinobac). Because of the assumption of the first-order process and passive diffusion, one would expect the plasma concentration of a drug at any time to be directly proportional to the dose administered however, the fundamental pharmacokinetic parameters of a dmg will remain unaffected by the administered dose. We plotted... 

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