Cinoxacin

This representation is intended to encompass 4-oxo-3-quinolinecarboxyhc acids as well as the corresponding 1,8-naphthyridines, cinnolines, and pyrido[2,3-<55pyrimidines. These classes are illustrated by ciprofloxacin [85721-33-1] (2) (1), naUdixic acid [389-08-2] (3) (2), cinoxacin [28657-80-9] (4) (3), and piromidic acid [19562-30-2] (5) (4), respectively. [Pg.451]

Ethyl (1-methyl-Aj-butenyDcyano-aceticacid ethyl ester Vinbarbital sodium 1 -Ethyl-6,7-methylenedioxy-4-(1H)-oxocinnoline-3-carbo nit rile Cinoxacin... [Pg.1634]

Examples of urinary anti-infectives include cinoxacin (Cinobac), fosfomycin (Monurol), metlienamine rnande-late (Mandelamine), nalidixic acid (NegGram), and nitrofurantoin (Puradantin). [Pg.457]

Cinoxacin is contraindicated in patients with known hypersensitivity to the individual drug and in patients with anuria. Cinoxacin is a Pregnancy Category B drug and should be used with caution during pregnancy and lactation. Cinoxacin is used with caution in patients with hepatic impairment. When cinoxacin is administered with probenecid, there is a risk for lowered urine concentration of cinoxacin. [Pg.460]

CCuN 544-92-3) see Cinoxacin Citalopram Lamotrigine Mabuterol Methallenestril Trimetrexate glucuronate Corey lactone... [Pg.2338]

C2H5I 75-03-6) see Butibufen Cinoxacin Diethylstilbestrol Enoxacin Ethotoin Gallamine triethiodide Imiquimod Lomefloxacin Mosapride citrate Nalidixic acid Oxolinic acid Pefloxacin Pipemidic acid Tridihexethyl chloride Zaleplon... [Pg.2381]

CO Ctjs Exafnpte Norfloadcjn o5 H Example NalidiiHc acid o6 M ExampiB. Cinoxacin... [Pg.121]

As noted earlier (see Chapter 12), considerable latitude exists in the nalidixic acid type antibacterial agents as to the exact nature of the two heterocyclic rings. The minimum requirement for activity seems to reside in a fused enaminoketone carboxylate function. (Even so, an additional nitrogen atom may be interposed in that function, viz. cinoxacin.) Consistent with this, it is interesting that inclusion of an additional nitrogen atom in the pyridino ring also gives a molecule (127) that shows... [Pg.469]

Transformation of the fluoroquinolones sarafloxacin to IV-acety I sarafloxaci n and d e s e t h v I e n e - N - ace tv I s a r afl o x ac i n by M. ramannianus [37] and flumequine to two diasteroisomers of 7-hydroxyflumequine and 7-oxoflumequine by C. elegans [38] was also reported. Meanwhile, the quinolone-like antibiotic cinoxacin produced 1-ethyl-l,4-dihydro-3-(hydroxymethyl)[l,3]dioxolo[4,5-g]cinnolin-4-one and 1 -ethyl-1,4-dihydro-6,7-dihydroxy-3-(hydroxymethyl)cinnolin-4-one when transformed by Beauveria bassiana [39]. [Pg.182]

Antibiotics Cinoxacin B. bassiana Experimental cultures in flasks 20 mM were incubated at 28° C with rotary shaking at 180 rpm during 20 days. 52.7% removed after 20 days 1 -Ethyl-1,4-dihydro-3-(hydroxymethy 1)- [1,3] dioxolo[4,5-g]cinnolin-4-one 1 Ethyl-1, [32]... [Pg.194]

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