Fluvastatin Cimetidine

Endocrine effects Statins interfere with cholesterol synthesis and lower circulating cholesterol levels and, as such, might theoretically blunt adrenal or gonadal steroid hormone production. Small declines in total testosterone with no commensurate elevation in LH have been noted with the use of fluvastatin. Pravastatin showed inconsistent results with regard to possible effects on basal steroid hormone levels atorvastatin, lovastatin, rosuvastatin, and simvastatin did not reduce basal plasma cortisol concentration or basal plasma testosterone concentration or impair adrenal reserve. Appropriately evaluate patients who display clinical evidence of endocrine dysfunction. Exercise caution when administering HMG-CoA reductase inhibitors with drugs that affect steroid levels or activity, such as ketoconazole, spironolactone, and cimetidine. 

CYP2C9 Inhibition Amiodarone, cimetidine, trimetho-primsulfamethoxazole, fluoxetine, fluvoxamine, isoniazid, itraconazole, ketoconazole, fluconazole, metro-nidasole, sulfinpyrazone, ticlopidine Fluvastatin Rosuvastatin ( ) ... 

Cimetidine, fluconazole, fluvastatin, isoniazid, lovastatin, pravastatin, simvastatin, sulfaphenazole, tienilic acid, tolbutamide, warfarin... 

A 59-year-old woman with type 2 diabetes mellitus and coronary artery disease, taking fenofibrate, hsinopril, metformin, fluvastatin, and atenolol, was given cimetidine for gastroesophageal reflux disease and immediately developed nausea and vomiting followed by diarrhea. She had low hemoglobin, carbon... 

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