Chronic myelogenous leukemia -derived

Imatinib (STI571) is an inhibitor of the tyrosine kinase domain of the Bcr-Abl oncoprotein and prevents the phosphorylation of the kinase substrate by ATP. It is indicated for the treatment of chronic myelogenous leukemia (CML), a pluripotent hematopoietic stem cell disorder characterized by the t(9 22) Philadelphia chromosomal translocation. This translocation results in the Bcr-Abl fusion protein, the causative agent in CML, and is present in up to 95% of patients with this disease. This agent inhibits other activated receptor tyrosine kinases for platelet-derived growth factor receptor (PDGFR), stem cell factor (SCF), and c-kit. 

Kattlove and his associates believe that the glucocerebroside which accumulates in Gaucher s disease is principally derived from polymorphonuclear cells which have a rapid turnover and are rich in ceramide lactoside [122]. (This explains the occasional presence of Gaucher cells in marrow of patients with chronic myelogenous leukemia.)... 

Usnic acid and its 9 derivatives Lymphocytic leukemia L 1210 Murine Lewis lung 3LL Chronic myelogenous leukemia K-562 Brain metastasis of prostate DU 145 Breast MCF 7 Glioblastrana U251 Hamster cell lines CHO and CHO-MG Bazin et al. (2008)... 

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