Chronic inflammation immunosuppression, associated with

Cyclosporin suppresses cell-mediated immune reactions and some humoral immunity. It is indicated in the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants in conjunction with adrenal corticosteroid therapy treatment of chronic rejection in patients previously treated with other immunosuppressive agents increased tear production in patients whose tear production is presumed to be suppressed because of ocular inflammation associated with keratoconjunctivitis sicca (ophthalmic emulsion). Gengraf, Neorai Used for treatment of severe active rheumatoid arthritis (RA) where disease is not adequately responsive to methotrexare treatment of adult, non-immunocompromised patients with severe, recalcitrant, plaque psoriasis who have failed to respond to a least one systemic therapy or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated. 

Patients with coeliac disease show the symptoms associated with malabsorption, often characterized by steatorrhoea (pale stools that float because of their high fat content) (22a). Malabsorption may have any number of causes, one of which is coeliac disease, a gluten-sensitive enteropathy. This disorder results in loss of villi, crypt hyperplasia and chronic inflammation of the small bowel mucosa. The immature cells of the small intestine are unable to absorb nutrients or to produce G1 hormones. This reduces pancreatic and bile secretion, which impedes fat absorption in the gut. Anaemia is caused by the folate and B12 deficiency due to impaired absorption (22b). Treatment of coeliac disease is by a gluten-free diet, steroids (to treat inflammation) and immunosuppressants (22c). People with unrecognized and untreated coeliac disease may have an increased risk of small bowel carcinoma. 

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