Chronic immune dysfunction syndrome

Frequently, MCS involves imbalances in one s nervous, immune, and endocrine systems, and impaired detoxification abilities. Conditions such as CFIDS (Chronic Fatigue Immune Dysfunction Syndrome), fibromyalgia, and Candida Syndrome are frequently found in people with MCS. It is not yet known whether these are separate diseases or whether they represent different manifestations of a common underlying problem. 

In 1986 I was diagnosed with chronic fatigue immune dysfunction syndrome (CFIDS) and my whole life as I knew it changed. Before I got sick I was a word processor during the day, and after work and on weekends I was singing professionally in clubs and concerts and teaching music. But after I got sick I was spending most of my time in bed. 

CFS, also known as Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), is a multisystem disorder with unknown etiology or pathophysiology. It is currently thought that CFS is a multifactorial condition in which an infective agent causes an aberrant immune response. It is characterized by extreme fatigue, immune system dysfunction, neurological and endocrine disorders, chronic pain, and numerous other symptoms. Many of those with CFS are extremely sensitive to chemical exposure. F9-34]... 

A secondary carnitine deficiency due to accumulation of propionyl-CoA and increased concentration of acylcamitines is also common [13]. Superficial desquamation, alopecia, and corneal ulcerations similar to staphylococcal scalded skin syndrome or acrodermatitis enteropathica-like syndrome, typically associated with diarrhea, may be seen secondary to acute protein malnutrition or essential amino acid deficiency, especially isoleucine deficiency [34, 52-54]. Immune dysfunction has also been suggested with an increased risk for viral or bacterial infections, but good studies are lacking [34]. Chronic moniliasis has been described and reflects the effect of propionyl-CoA and methylmalonate on T-cell number and function [7], Finally, acute and chronic pancreatitis, osteopenia or osteoporosis, and ovarian failure may also occur the etiologies of which remain unclear [3, 7, 24, 34, 36,47, 55-59],... 

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