Staphylococcal scalded skin syndrome

PA S1 S01.270 Exfoliatin A Drug target in staphylococcal scalded skin syndrome... 

Staphylococcal scalded skin syndrome developed in a 68-year-old man after he had taken diclofenac for knee arthritis subsequently diagnosed as septic arthritis due to Staphylococcus aureus (33). 

Oono T, Kanzaki H, Yoshioka T, Arata J. Staphylococcal scalded skin syndrome in an adult. Identification of exfoliative toxin A and B genes by polymerase chain reaction. Dermatology 1997 195(3) 268-70. 

A secondary carnitine deficiency due to accumulation of propionyl-CoA and increased concentration of acylcamitines is also common [13]. Superficial desquamation, alopecia, and corneal ulcerations similar to staphylococcal scalded skin syndrome or acrodermatitis enteropathica-like syndrome, typically associated with diarrhea, may be seen secondary to acute protein malnutrition or essential amino acid deficiency, especially isoleucine deficiency [34, 52-54]. Immune dysfunction has also been suggested with an increased risk for viral or bacterial infections, but good studies are lacking [34]. Chronic moniliasis has been described and reflects the effect of propionyl-CoA and methylmalonate on T-cell number and function [7], Finally, acute and chronic pancreatitis, osteopenia or osteoporosis, and ovarian failure may also occur the etiologies of which remain unclear [3, 7, 24, 34, 36,47, 55-59],... 

Staphylococcus bacteria are one of the most common causes of skin infection. There are many kinds of staphylococcal skin infections. The least serious is folliculitis, an infection of a hair root that produces a slightly painful pimple at the base of a hair. Most of these infections are minor (pimples and boils) however. Staphylococcus bacteria may also cause serious infections. Impetigo causes shallow, fluid-filled blisters and may itch or hurt. Staphylococcus skin abscesses are warm, painful, collections of pus below the skin surface and staphylococcus cellulitis is a spreading infection that develops under the skin producing pain and redness. More serious skin infections include toxic epidermal necrolysis and scalded skin syndrome in newborns. 

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