Chronic fatigue syndrome pathophysiology

Mood disorders are commonly seen in general medical practice and some general medical disorders resemble depression in important respects. In particular, both fibromyalgia and chronic fatigue syndrome are medical disorders that have clinical and pathophysiologic features in common with atypical depression. 

As can be seen from this list of symptoms, many are emblematic of multiple chemical sensitivity and chronic fatigue syndrome. This crossover of symptoms often complicates the diagnosis of FM. Mechanistically, oxidative stress and nitric oxide are believed to play a role in FM pathophysiology however, it is not clear at this time whether the oxidative stress abnormalities found in FM are the cause or the effect J46 59 ... 

Dysautonomias also range from mechanistically straightforward disorders in which altered autonomic function plays a primary pathophysiological role (e.g., pure autonomic failure), to conditions in which altered autonomic fimction worsens an independent pathophysiological state (e.g., cardiac failure), and to more mysterious disorders in which the involvement of the autonomic nervous system is less clear (e.g., chronic fatigue syndrome). Abnormalities of blood pressure control represent the common presenting cfinical features of the dysautonomias. In those involving... 

CFS, also known as Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), is a multisystem disorder with unknown etiology or pathophysiology. It is currently thought that CFS is a multifactorial condition in which an infective agent causes an aberrant immune response. It is characterized by extreme fatigue, immune system dysfunction, neurological and endocrine disorders, chronic pain, and numerous other symptoms. Many of those with CFS are extremely sensitive to chemical exposure. F9-34]... 

---