Chromosome components

Luger K, Richmond TJ (1998) DNA binding within the nucleosome core. Curr Opin Struct Biol 8 33-40 MacCallum DE, Losada A, Kobayashi R, Hirano T (2002) ISWl remodeling complexes in Xenopus egg extracts identification as major chromosomal components that are regulated by INCENP-aurora B. Mol Biol Cell 13 25-39... 

MacCallum DE, Losada A, Kobayashi R, Hirano T (2002) ISWI remodeling complexes in Xenopus egg extracts identification as major chromosomal components that are regulated by INCENP-aurora B. 

Moore, G., L. Aragon-Alcaide, M. Roberts, S. Reader, T. Miller, and T. Foote. 1997. Are rice chromosomes components of a holocentric chromosome ancestor Plant Mol Biol 35 17-23. 

FIGURE 11.22 If the cell walls of bacteria such as Escherichia coli are partially digested and the cells are then osmotlcally shocked by dilution with water, the contents of the cells are extruded to the exterior. In electron micrographs, the most obvious extruded component is the bacterial chromosome, shown here surrounding the cell. (Dr. Gopal Murti/CNRI/Phototakr NYC)... 

Figure 52-7. Simplified scheme of the sequence of events involved in the causation of chronic granulomatous disease (MIM 306400). Mutations in any of the genes for the four polypeptides involved (two are components of cytochrome b55gand two are derived from the cytoplasm) can cause the disease. The polypeptide of 91 kDa is encoded by a gene in the X chromosome approximately 60% of cases of chronic granulomatous disease are X-linked, with the remainder being inherited in an autosomal recessive fashion.

The Physiome Project will undoubtedly benefit from lessons learned during the progress of the Genome Project, in particular, that big visions and small steps (at least initially) are not necessarily a contradiction. It will, however, have to develop a completely different approach to problem solving than that used for the Genome Project, as neither the total dimension of the task (there are only 23 human chromosome pairs) nor the size of the smallest component that needs investigating (DNA bases) can be defined at the outset of the Physiome Project. 

Kanaya N, Gill BS, Grover IS, Murin A, Osiecka R, Sandhu SS, Andersson HC (1994) Vicia faba chromosomal aberration assay. Mutat Res 310 231-247 Matsuda H, Ose Y, Nagase H, Sato T, Kito H, Sumida K (1991) Mutagenicity of the components of ozonated humic substance. Sci Total Environ 103 129-140... 

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