Chromosome aberration test purpose

Under the Industrial Safety and Health Law, unlike the Chemical Substances Control Law, all chemical substances including a chemical substance regulated by other laws, such as the Food Sanitation Law in lapan and the Pharmaceutical Affairs Law, and used exclusively for the purpose permitted by such laws must be notified. Notification of a substance is accepted if it shows a negative result for the test and the notification document is complete. On acceptance, the substance can be manufactured and / or imported. If the substance shows a positive result for the test, the competent authority requires that additional tests be performed, such as a chromosomal aberration test, and the provision to workers who handle the substance with the information on safety, handling methods and emergency measures for the substance described in a Material Safety Data Sheet (MSDS). 

Purpose. The purpose of the in vivo chromosome aberration test is to evaluate the potential of the test substance to cause chromosomal aberrations in bone marrow cells of experimental animals (usually rodents) (Tice et al. 1994 Preston et al. 1987). 

The spermatogonial test is used to identify substances that cause structural chromosome aberrations in mammalian spermatogonial cells, and is designed to investigate whether somatic cell mutagens are also active in germ cells. This test is not designed to measure numerical aberrations and is not routinely used for this purpose. 

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