Chromatography optimization

Golshan-Shirazi, S. and Guiochon, G., Theory of optimization of the experimental conditions of preparative liquid chromatography optimization of column efficiency, Anal. Chem., 61, 1368, 1989. 

Persson-Stubberud, K., Forsberg, A., Callmer, K., and Westerlund, D. (2002). Partial filling micellar electrokinetic chromatography optimization studies of ibuprofen, codeine and degradation products, and coupling to mass spectrometry. Electrophoresis 23, 572—577. 

JA Bietz, T Burnouf, LA Cobb, JS Wall. Gliadin analysis by reversed-phase high-performance liquid chromatography optimization of extraction conditions. Cereal Chem 61 124-129, 1984. 

St. Martin, M. and Paquin, P. (1990). Ion exchange fast protein liquid chromatography, optimization of the purification of caseins using a non-denaturing detergent.. Dairy Res. 57, 63-68. 

K. Grob, Concurrent eluent evaporation with co-solvent trapping for on-line reversed-phase liquid chromatography-gas chromatography. Optimization of conditions , J. Chromatogr. 477 73-86 (1989). 

Resolution can often be improved in liquid chromatographic separations simply by changing the retention of the components, which corresponds to changing the capacity factor k of the components to be separated. Rapid increases in the third term in Eq. (5), 2/(1 + 2). occur as the capacity factor increases, up to 2 = 5. The term increases only slowly beyond this value [2]. Therefore, in most separations by liquid chromatography, optimal resolution of mixtures occurs when each component has capacity factor values between 2 and about 10. Increasing k values to higher values results in longer analysis times with minimal improvements in resolution [2]. 

Depending upon the different forms of chromatography, optimization can be more or less rapid. In gas phase chromatography optimization is easier to achieve than in liquid chromatography in which the composition of mobile phase must... 

Soczewihski, E. Stepwise gradient development in thin-layer chromatography. Optimization of gradient program. J. Chromatogr. 1986, 369, 11-17. 

The basic simplex optimization method, first described by Spendley and co-workers in 1962 [ 11 ], is a sequential search technique that is based on the principle of stepwise movement toward the set goal with simultaneous change of several variables. Nelder and Mead [12] presented their modified simplex method, introducing the concepts of contraction and expansion, resulting in a variable size simplex which is more convenient for chromatography optimization. 

Klinkenberg, H., van der Wal, S., de Koster, C. and Bart,J. (1998). On the use of inductively coupled plasma mass spectrometry as an element specific detector for liquid chromatography Optimization of an industrial tellurium removal process./ Chromatogr. 794(1—2), 219. 

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