Chromatographic data system

Papas, A. N., Chromatographic data systems a critical review, CRC Crit. Rev. Anal. Chem., 20, 359, 1989. 

McConnell, M., Canales, M., and Lawler, G., A validation protocol for analog-to-digital interfaces in chromatographic data systems, LC-GC, 9, 486, 1991. 

Good chromatographic data systems allow users to perform data processing online but asynchronously. This means that data acquisition for the next sample on the list starts directly and the processing of the prior sample starts as soon as computer resources are available. 

MS as a gas chromatographic detector has become much simpler to operate in the past decade. Nearly all control of the detector is performed through a data system with similar look-and-feel to other chromatographic data systems. Components such as ion sources now have less than 10 parts, making periodic cleaning and maintenance much simpler than in the past. Finally, the pricing of mass selective detectors is now similar to other selective detectors. It is likely that MS will eventually supplant most of the other selective detectors. 

Beyond simple data storage and instrument control, modern data systems provide extensive data analysis capabilities, including fitted baselines, peak start and stop tic marks, named components, retention times, timed events and baseline subtraction. Further, they provide advanced capabilities, such as multiple calibration techniques, user-customizable information and reports and collation of multiple reports. If a Laboratory Information Management System (LIMS) is available, the chromatographic data system should be able to directly transfer data files and reports to the LIMS without user intervention. The chapter by McDowall provides a terse but thorough description of the... 

As shown in the Level column of Figure 10, the various injected volumes can be designated as individual component calibration levels. By doing this, experiments 10-27 can also be used to help validate multilevel, multi-replicate calibration algorithms on a chromatographic data system. 

The authors wish to thank L. Moody for performing the data transfer from the Nelson chromatographic data system to the DEC 11/23+ and D. Harwood for performing the closure analysis. 

Multivariate analysis is not a panacea for all flavor problems. It is a valuable tool which should be used in conjunction with other sensory and analytical skills to solve flavor problems. The availability of a programmable chromatographic data system makes implementation of MVA straightforward. 

Most of the instruments used in the laboratory are commercial off-the-shelf (COTS) instruments, and consequently the users have little or no input into their design. A full system development life-cycle (SDLC) approach [8], which is used to develop complex computerized systems such as Laboratory Information Management System (LIMS) or Chromatographic Data System (CDS) or custom design laboratory equipment, is not appropriate for COTS instruments. Some laboratory instruments such as a pH meter or centrifuge are fairly simple and therefore do not warrant the SDLC approach. 

If the peaks/fractions are directly submitted to the NMR spectrometer for measurement under static conditions, the chromatographic data system must be capable of pausing the separation. This includes not only an interruption of the flow but also the gradient generation and acquisition of the chromatogram. Otherwise, later peaks will be lost and subsequent measurements of multiple peaks from one chromatogram will not be possible. 

Apparatus Gas chromatograph with flame ionization detector (Flewlett-Packard 5890 Series n, or equivalent) equipped with a 5- xL syringe for 0.32-mm (id) columns. Automatic sampler (HP 7673, or equivalent). Chromatographic data system or integrator (HP 3365 Series II software, or equivalent). Retention gap, deactivated fused silica, 1-mm x 0.32-mm (id) with capillary column connectors. DB 5-HT,... 

High Pressure Liquid Chromatographic Data Systems HB to HD 1123... 

Tests should be developed for each subsystem, and each subsystem should be validated. Again, the vendor should provide validated software to automatically execute these tests. An example was shown above for chromatographic data systems. 

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