Chromatin-remodeling complexes recruitment

Goldmark, J.P., Fazzio, T.G., Estep, P.W., Church, G.M., and Tsukiyama, T. (2000) The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell 103, 423-433. 

Wallberg, A.E., Neely, K.E., Hassan, A.H., Gustafsson, J.A., Workman, J.L., and Wright, A.P. (2000) Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor taul activation domain. Mol. Cell. Biol. 20, 2004-2013. 

Fig. 4 Co-activator and co-repressor complexes are required for nuclear hormone receptor-mediated transcriptional regulation. The tissue-selective fine-tuning of gene transcription by nuclear hormone receptors is due to different co-regulatory complexes that have various functions and enzymatic activities. Co-activator complexes include factors that contain ATP-dependent chromatin remodelling activity often associated with histone acetyltransferase (HAT) activity. Co-repressors include ATP-dependent chromatin remodelling complexes, which function as platforms for the recruitment of several subcomplexes that often contain histone deacetylase (HDAC) activity...

RAR RXR complexes are known to bind to DNA response elements loosely and recruit an ATP-dependent, chromatin remodeling complex known as ISWI to the template (151). ISWI-mediated remodeling of chromatin seems to allow apo-RAR-RXR complexes to bind to the DNA response element much more tiightly (151). Presumably, apo-RAR-RXR... 

Fig. 1.34 Model of the action of transcriptional regulators and chromatin-remodeling complexes (After Narlikar et al., 2002). To prepare the DNA template for transcription, condensed chromatin is reorganized and becomes accessible for the binding of transcriptional regulators and remodeling complexes. In the model shown, the transcriptional regulator binds first to its DNA element and then recruits histone acetylase (HAT) complexes to the...

Fig. 4.11 Model of repression and activation of T3R. In the absence of the T3 hormone, a hetero-dimeric RXR-T3R receptor is bound at the T3-re-sponsive element,TRE, establishing a basal repressed state. The repressed state is maintained by recruitment of corepressor complexes containing histone deacetylase activity. X refers to potential unidentified cofactors (possibly chromatin remodeling complexes or SRBs) which help to keep the promotor-bound basal transcription apparatus in...

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