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Chromatin damage

Characterization of various types of damage to DNA by oxygen-derived species can be achieved by the technique of gas chromatography-mass spectrometry (GC-MS), which may be applied to DNA itself or to DNA-protein complexes such as chromatin (Dizdaroglu, 1991). For GC-MS, the DNA or chromatin is hydrolysed (usually by heating with formic acid) and the products are converted to volatile derivatives, which are separated by gas chromatography and conclusively identified by the structural evidence provided by a mass spectrometer. Stable isotope-labelled bases may be used as internal standards... [Pg.206]

Dizdaroglu, M., Rao, G., Halliwell, B. and Gajewski, E. (1991a). Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions. Arch. Biochem. Biophys. 285, 317-324. [Pg.211]

Kasprzak, K.S., Diwan, B.A., Rice, J.M., Misra, M., Riggs, C.W., Olinski, R and Dizdaroglu, M. (1992). Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis. Chem. Res. Tox. 5, 810-815. [Pg.212]

Lett, J.T. 1990. Damage to DNA and chromatin structure from ionizing radiations, and the radiation sensitivities of mammalian cells. Prog. Nucleic Acid Res. Molec. Biol. 39 305-352. [Pg.1745]

Downs JA, Allard S, Jobin-Robitaille O, Javaheri A, Auger A, Bouchard N, Kron SJ, Jackson SP, Cote J (2004) Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell 16 979-990... [Pg.106]

Sensing DNA damage is essential for maintenance of genomic integrity and cell cycle progression. DNA repair is the second major site of DNA synthesis in a cell after replication and it involves chromatin assembly after efficient repair process. In yeast, the histone chaperone CAF-1 (chromatin Assembly factorl) mediates histone H3-H4 assembly on to newly replicated DNA and also mediates nucleotide... [Pg.118]

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Chromatin

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