Cholinergic differentiation factor

A number of proteins influence neurotransmitter traits in sympathetic neurons (Fukada, 1985 Kessler et al., 1986 Saadat et al., 1989). Sympathetic cholinergic differentiating factor and leukemia inhibitory factor are the same 45 kDa glycoprotein molecule (Yamamori et al., 1989) which increases CAT activity and decreases tyrosine hydroxylase activity (Fukada, 1985). A 22 kDa protein isolated from rat sciatic nerve, ciliary neurotrophic factor (Manthorpe et al., 1986 Lin et al., 1989 Stockii et al., 1989) has a similar effect (Saadat et al., 1989). It appears that the two molecules act via the same receptor complex (Ip et al.,... 

Banner, L.R. and Patterson, P.H. (1994) Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia. Proc. Natl. Acad. Sci. USA 91 7109-7113. 

Rao, M.S. and Landis, S.C. (1990) Characterization of a target-derived neuronal cholinergic differentiation factor. Neuron 5 899-910. 

Mahendra, Y.S., Rao, S., Zigmond, R.E. and Landis, S.C. (1994) Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy the role of cholinergic differentiation factor/leukemia inhibitory factor. J. Neurobiol. 25 415-430. 

Martinou, J.C., Martinou, 1. and Kato, A.C. (1992) Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro. Neuron 8 737-744. 

IgE-detergent complex Cholinergic differentiation factor Nonidet P-40 0.74 77N1... 

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