Sympathetic cholinergic differentiating factor

A number of proteins influence neurotransmitter traits in sympathetic neurons (Fukada, 1985 Kessler et al., 1986 Saadat et al., 1989). Sympathetic cholinergic differentiating factor and leukemia inhibitory factor are the same 45 kDa glycoprotein molecule (Yamamori et al., 1989) which increases CAT activity and decreases tyrosine hydroxylase activity (Fukada, 1985). A 22 kDa protein isolated from rat sciatic nerve, ciliary neurotrophic factor (Manthorpe et al., 1986 Lin et al., 1989 Stockii et al., 1989) has a similar effect (Saadat et al., 1989). It appears that the two molecules act via the same receptor complex (Ip et al.,... 

Mahendra, Y.S., Rao, S., Zigmond, R.E. and Landis, S.C. (1994) Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy the role of cholinergic differentiation factor/leukemia inhibitory factor. J. Neurobiol. 25 415-430. 

Saadat, S., Sendtner, M., Rohrer, H., 1989. Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. J. Cell Biol. 108 (5), 1807-1816. 

Ure, D.R., Campenot, R.B. and Acheson, A. (1992) Cholinergic differentiation of rat sympathetic neurons in culture Effects of factors applied to distal neurites. Dev. Biol. 154 388-395. 

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