Choline phosphokinase

The effects of lead on endogenous enzymes involved in cholinergic metabolism are also uncertain. Sobotka et al. (1974) showed decreases in activity of acetylcholinesterase, while Carroll et al. (1977) found that acetylcholinesterase, choline acetyltransferase and choline phosphokinase were not altered by lead. However, Modak et al. (1975) demonstrated differential effects of acetylcholinesterase and choline acetyltransferase in discrete areas of brain lead treatment changed these enzymes in opposite directions. Acetylcholinesterase had significantly lower activity in the diencephalon,... 

Choline is converted to phosphorylcholine by an enzyme found in yeast and several animal tissues. This enzyme, choline phosphokinase, catalyzes the reaction ... 

Mg Polynucleotide phosphoryla.ee. ATPase. choline acylase, deoxyribonuclease, acetate kinase, adenosine phosphokinase, tructokinase. glyceric kinase, hexokinase Chlorophyll... 

When deprived of dietary choline, healthy male subjects have diminished plasma concentrations of choline and phosphatidylcholine, and they develop liver cell death (elevated plasma alanine aminotransferase). In similarly deprived animal models, the liver cell death is caused by apoptosis, a regulated form of cell suicide. In an ongoing study of choline deficiency in humans, muscle cell death (elevated plasma creatine phosphokinase, MM form) has also been noted. 

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