Cholesterol pullulan

Akiyoshi K, Kobayashi S, Shichibe S et al (1998) Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs Complexation and stabilization of insulin. J Control Release 54 313-320... 

Cholesterol-bearing pullulan nanogels are capable of binding various hydrophobic substances and have been used for the delivery of some hydrophobic, anticancer therapeutics such as adriamycin and doxorubicin. " ... 

Iwamoto et al. suggested that the tissue distribution of an O/W emulsion can be controlled by coating their surfaces with a cell-specific cholesterol-bearing polysaccharide, such as pullulan, amylopectin, and mannan (10,24). 

Coating of emulsion particles with cholesterol-bearing polysaccharides, such as pullulan, amylopectin, and mannan, led to a reduction of the divalent metal ion-induced aggregation of Che emulsion droplets. The cholesteryl group behaves as a hydrophobic anchor in the surface lipid layer resulting in a lower fluidity of the. surface of the emulsion droplets (24). 

Regular surface-rehef calcium carbonate structures were prepared by a cooperated directing agent of soluble poly(acryhc acid) (PAA, Mw = 2000) and a substrate of cholesterol-bearing pullulans (Fig. 15) [231]. At low temperature, adapted PAA concentration, and with cholesteryl groups, a high quality periodic calcite structure can be formed by a self-organization process in the reaction-diffusion system with competition between precipitation and ion diffusion. 

Pullulan (from 23) Hexamethylen diurethane- cholesterol SDS micelle -2.7 - 1... 

Deguchi, S. Kuroda, K. Akiyoshi, K. Lindman, B. Sunamoto, J. Gelation of cholesterol-bearing pullulan by surfactant and its rheology. Colloid and surfaces A 1999, vol 147, 203-211. 

First, the partition of hydrophobized polysaccharide (HP)-coated liposomes was investigated in aqueous two-phase systems such as polyfethylene oxide) (PEO) (top phase)/pullulan (bottom phase) and poly(ethylene oxide) (top)/ dextran (bottom phase). HPs such as cholesterol-bearing pullulan, dextran, and mannan nicely coated the liposomal surface. When conventional uncoated liposomes were added to the aqueous two-phase system, they mostly located at the interface between the two polymer phases. The HP-coated liposomes, on the other hand, were significantly partitioned into the bottom polysaccharide phase, depending on the structure of the HP on the liposomal surface. 

The d/-a-Dipalmitoyl phosphatidylcholine (DPPC) (purity, 99% Sigma, St. Louis, MO), cholesterol (Nacalai Tesque, Kyoto, Japan), pullulan-50 [mo-... 

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