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Cholesterol-binding domain

Di Scala C, Yahi N, Lehevre G, Garmy N, Chahinian H, Fantini J. Biochemical identification of a linear cholesterol-binding domain within Alzheimer s beta amyloid peptide. ACS Chem Neurosci. 2013 4(3) 509-517. Molander-Mehn M, Blennow K, Bogdanovic N, DeUheden B, Mansson JE, Fredman P. Structural membrane alterations in Alzheimer brains found to be associated with regional disease development increased density of gangHosides GMl and GM2 and loss of cholesterol in detergent-resistant membrane domains. J Neurochem. 2005 92(1) 171-182. [Pg.105]

An important caveat in the predictive value of the CRAC algorithm is that in some cases, it may correctly identify a cholesterol-binding domain, but outside the membrane bilayer. [Pg.141]

In conclusion, the CARC domain has been detected in a wide range of type I and type III membrane proteins, including ion channels and GPCR proteins. Its unique biochemical features are particularly consistent with the definition of a consensus cholesterol-binding domain ensuring the specific interaction of TM domains with membrane cholesterol. Its definition is recapitulated in a simple algorithm that reflects basic principles of protein-lipid interactions in a membrane environment. [Pg.144]

Fantini J, Carlus D, Yahi N. The fusogenic tilted peptide (67-78) of alpha-s)muclein is a cholesterol binding domain. Biochim Biophys Acta. 2011 1808(10) 2343-2351. [Pg.160]

Fantini J, Yahi N. The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells key role of gangHoside- and cholesterol-binding domains. Adv Exp Med Biol. 2013 991 15-26. [Pg.160]

Corbin J, Wang HH, Blanton MR Identifying the cholesterol binding domain in the nicotinic acetylcholine... [Pg.179]

FIGURE 10.8 Tilted orientation of a-synuclein upon cholesterol binding. The models were obtained by molecular dynamics simulations of the cholesterol-a-synuclein complex. (A) The a-heUx of a-synuclein (a-syn) is colored in red and cholesterol (chol) in yellow. (B) Surface view of the complex (cholesterol in yeUow). (C) Tilted topology of the complex. The angle between the helix axis of the tilted cholesterol-binding domain of a-synuclein and the main axis of cholesterol is 46°. (D) Surface view illvistrates the close contact between cholesterol and a-synuclein (cholesterol wraps around the a-helix of the tilted cholesterol-binding domain). (Reproduced from Fantini et with permission from Elsevier.)... [Pg.237]

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See also in sourсe #XX -- [ Pg.140 , Pg.191 ]



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Cholesterol binding

Cholesterol-binding domain CRAC motif

Cholesterols domains

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