Cholestasis recurrent intrahepatic

During cholestasis, the metabolism of tolbutamide is greatly altered, thus, tolbutamide (100 mg/kg) injected i.v. into rats with experimental cholestasis was eliminated more rapidly than in control animals, this increase was owing to the increase in liver weight and microsomal protein (25). In patients with recurrent intrahepatic cholestasis no differences in tolbutamide metabolism were noted as compared to the control group. In cholestatic hepatitis the plasma half-life of tolbutamide appeared unchanged. The... 

Further intrahepatic forms of obstruction include recurrent intrahepatic cholestasis and recurrent cholestasis in pregnancy, (s. tab. 12.4)... 

Fig. 13.3 Scratch marks resulting from pruritus in recurrent intrahepatic cholestasis...

Aagenaes, O., van der Hagen, C.B., Refsum, S. Hereditary recurrent intrahepatic cholestasis from birth. Arch. Dis. Childh. 1968 43 646-657... 

F. Successful chnical apphcation of extracorporal albumine dialysis in a patient with benign recurrent intrahepatic cholestasis (BRIC). Z. Gastroenterol. 2001 39 (Suppl. 2) 13-14... 

G. Benign recurrent intrahepatic cholestasis. A clinico-pathologic study. Res. Clin. Lab. 1990 20 19-27... 

Nakamuta, M., Sakamoto, S., Miyata, Y., Sato, M., Nawata, H. Benign recurrent intrahepatic cholestasis a long-term follow-up. Hepat. Gastroenterol. 1994 41 287 - 289... 

Sturm, E., Franssen, CJtJM., Gouw, A., Staels, B., Boverhof, R., de Knegt, R.J., Stellaard, F., Biileveld, C.MA., Kuipers, F. Extracorporal albumin dialysis (MARS) improves cholestasis and normalizes low apo A-I levels in a patient with benign recurrent intrahepatic cholestasis (BRIC). Liver 2002 22 (Suppl. 2), 72-75... 

Bile-duct hypoplasia has also been observed in the Aagenaes syndrome of recurrent intrahepatic cholestasis (s. p. 233), in Turkish non-syndromic paucity of interlobular bile ducts (N. Kocak et al., 1997), etc. 

Cystine storage disease Gaucher s disease Glycogen stora ge disease Juvenile, Tay-Sachs disease Niemann-Pick disease Tay-Sachs disease Chronic renal failure Hemolytic-uremic syndrome Nephrotic syndrome Benign recurrent intrahepatic cholestasis... 

H21. Holzbach, R. T., and Sanders, H. W., A unique response to synthetic oestrogen progestational hormone in a familial case of recurrent intrahepatic cholestasis of pregnancy. Oastroenterology 48, 822-826 (1965). 

The remaining 59 patients, with relatively low serum bile acid concentrations (SGLC = 2.2 0.3,GC = 2.2 0.3, 3a-hydroxy bile acids = 10.3 0.9), included patients with mild liver disease, intestinal dysfunctions such as Crohn s disease, coeliac disease and gastroenteritis, acute lymphatic leukemia treated with methotrexate, contaminated small bowel syndrome and three patients with benign recurrent intrahepatic cholestasis (BRIC). 

Serum concentration of sulfated lithocholic acid conjugates (SGLC) and glycocholic acid (GC) in two brothers with benign recurrent intrahepatic cholestasis after oral fat loading at t = 0 hours A. during a symptom-free period B. as A, cholestyramine added C. during a pre-icteric period. 

Huinink and K. H. Brandt, Familial benign recurrent intrahepatic cholestasis Interrelation with intrahepatic cholestasis of pregnancy and from oral contraceptives, Gastroenterol., 71 202 (1976). 

Mild liver dysfunction, hypophosphatemia, and hypomag-nesmia are the most common laboratory abnormahties caused by aldesleukin (76,77). About 20% of patients develop mild to severe intrahepatic cholestasis with reversible and dose-dependent rises in bilirubin and alkahne phosphatase while serum transaminases were only shghtly increased (4,78). Recurrence of cholestasis after aldesleukin rechallenge was not always observed (79). The mechanism of aldesleukin-induced intrahepatic cholestasis is unknown, but it might be mediated by activation of Kupfer cells and the subsequent release of cytokines (SEDA-20, 335). Focal fatty infiltrates of the liver mimicking metastases were also reported in a patient receiving both aldesleukin and a short course of interferon alfa (80). 

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