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Tolbutamide metabolism

Most reports of this interaction have described hypoglycemia with tolbutamide in combination with sulfaphenazole (184,185,188,189), sulfafurazole (185), or co-trimoxazole (187,190). The inhibitory effect of sulfonamides on tolbutamide metabolism is mediated by CYP2C9 (191). [Pg.453]

Pond SM, Birkett DJ, Wade DN. Mechanisms of inhibition of tolbutamide metabolism phenylbutazone, oxyphenbu-tazone, sulfaphenazole. Clin Pharmacol Ther 1977 22(5 Pt l) 573-9. [Pg.458]

During cholestasis, the metabolism of tolbutamide is greatly altered, thus, tolbutamide (100 mg/kg) injected i.v. into rats with experimental cholestasis was eliminated more rapidly than in control animals, this increase was owing to the increase in liver weight and microsomal protein (25). In patients with recurrent intrahepatic cholestasis no differences in tolbutamide metabolism were noted as compared to the control group. In cholestatic hepatitis the plasma half-life of tolbutamide appeared unchanged. The... [Pg.731]

Darby et al (27) have reported that there is no significant correlations were found between the hepatic microsomal kinetic constants for l C-tolbutamide metabolism in vitro and the plasma half-lives and plasma clearance of the drug adminstered orally. [Pg.733]

Veronese ME, Miners JO, Randies D, et al. Validation of the tolbutamide metabolic ratio for population screening with the use of sulfaphenazole to produce model phenotypic poor metabolizers. Cbn Pharmacol Ther 1990 47 403 411. [Pg.79]

Tang C, Lin Y, Rodrigues AD, et al. Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes an impact more than protein binding. Drug Metab Dispos 2002 30 648-654. [Pg.356]

Tolbutamide, metabolized by CYP2C9 1590 Toll-like receptor (TLR)... [Pg.1882]

Skovsted L, Kristensen M, Hansen M, Siersbsek-Nielsen K. The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta Med Scand (1976) 199,513-15. [Pg.381]

Kater RMH, Tobon F, Iber FL. Increased rate of tolbutamide metabolism in alcoholic patients. JAMA (1969) 207, 363-5. [Pg.475]

In a study using tolbutamide as a probe drug for CYP2C9, posaconazole 200 mg once daily for 10 days had no effect on tolbutamide metabolism. ... [Pg.480]

Posaconazole slightly enhanced the blood glucose-lowering effects of glipizide in healthy subjects, but the clinical relevance of this is not known. Posaconazole does not appear to affect tolbutamide metabolism. [Pg.481]

Adebayo GI, Coker HAB. Lack of efficacy of cimetidine and ranitidine as inhibitors of tolbutamide metabolism. EurJ Clin Pharmacol (1988) 34,653-6. [Pg.492]

Aprepitant is an inducer of the cytochrome P450 isoenzyme CYP2C9 by which tolbutamide is metabolised. It therefore increases tolbutamide metabolism, which leads to a reduction in tolbutamide levels. However, the clinical relevance of these small changes has not been assessed. The manufacturer recommends caution when both drugs are given. ... [Pg.515]

Tassaneeyakul W, Veronese ME, BirkettDJ,DoeckeCJ, McManus ME, Sansom LN, Miners JO, Co-regulation of phenytoin and tolbutamide metabolism in humans. BrJ Clin Pharmacol 0992) 34, 494-8. [Pg.550]

SieiBbaek-Nielsen K, Hansen JM, Skovsted L, Lumholtz B, Kamiimann J. Sulphamethizole-induced inhibitic i of diphenylhyi toin and tolbutamide metabolism in man Clin Pharmacol Ther( 973) 14,148... [Pg.566]

Scott J, Poffenbarger PL (1978) Pharmacogenetics of tolbutamide metabolism in humans. Diabetes 28 41-51... [Pg.700]

See other pages where Tolbutamide metabolism is mentioned: [Pg.79]    [Pg.725]    [Pg.1350]    [Pg.409]    [Pg.481]    [Pg.575]    [Pg.261]    [Pg.68]   
See also in sourсe #XX -- [ Pg.59 , Pg.59 , Pg.79 ]

See also in sourсe #XX -- [ Pg.68 , Pg.69 , Pg.178 ]



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