Cholera Toxin B Subunit CTB

Intravaginal vaccination with whole cell and cholera toxin B subunit (CTB) oral cholera vaccine provided a greater success rate in providing a mucosal immune response in the female genital tract than an oral vaccination [152]. This study demonstrated that in a single individual, systemic immunity did not directly reflect the local antibody response in the mucosal... [Pg.424]

Datiche F, Luppi P-H, Cattarelli M. 1995. Serotonergic and non-serotonergic projections from the raphe nuclei to the piriform cortex in the rat A cholera toxin B subunit (CTb) and 5-HT immunohistochemical study. Brain Res 671 ... [Pg.187]

A cholera vaccine, comprising killed Vibrio cholerae cells and the recombinant cholera toxin B (CTB) subunit (the CTB subunit is used extensively as an adjuvant in mucosal immunization protocols, as it... [Pg.293]

V. cholerae B subunits of the cholera toxin (CTB) Potato Receptor-binding activity. Immunogenic in mice when delivered orally. Mice challenged intraileally with CT showed up to 60% reduction in diarrheal fluid accumulation in small intestines. 117, 118... [Pg.149]

V. cholerae B subunits of the cholera toxin (CTB) Tobacco leaf chloroplast No immunogenicity assays performed. 119... [Pg.149]

Vibrio cholera, the bacterium that causes cholera, colonizes the small intestine and produces cholera enterotoxin, which, as a consequence, brings about various symptoms including watery diarrhea. Cholera toxin is made up of a single A subunit of 27 kDa (CTA) and a nontoxic pentamer of B subunits of 11.6 kDa (CTB) together, these form a hexameric multi mer (Daniell et al., 2001). The A subunit has ADP ribosyl-transferase activity and facilitates entry of the toxin into epithelial cells. When administered... [Pg.70]

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