Chloroformic acid methylester

Azidoformic Acid Methytester (Azidoameisen-saure-methylester, Triazoameisensaure-methylester, Carbazidsaure-methylester or Stickstoffkohleasaure-methylester in Ger), N3.CO.O.CH3 mw 101.06, N 41.58%, OB —55.4% colorless liq, bp 102—3° exploded occasionally when distilled under atm pressure. May be prepd by warming for 1 hr ethereal soln of Am azide with methyl ester of chloroformic acid, Cl.CO.O.CHg. 

PUFA mix accurately weigh each of the fatty acid methylesters and dissolve these in 50 ml chloroform, reaching a concentration level that is identical to that of the internal standard. Add 200 mg BHT to the solution in order to prevent oxidation of the fatty acids. 

SYNS CHLORAMEISENSAEURE METHYLESTER (GERMAN) CHLOROCARBONATE de METHYLE (FRENCH) CHLOROCARBONIC ACID METHYL ESTER CHLOROFORMIC ACID METHYL ESTER MCF METHOXYCARBONYL CHLORIDE METHYLCHLOORFORMIAT pUTCH) METHYL CHLOROFORMATE pOT) METILCLOROFORMIATO (ITALIAN) RCRA WASTE NUMBER LT56... 

Preparation of the Time Index Standard Mixture (FAMEs) Methyl caprylate, methyl pelargo-nate, methyl caprate, methyl laurate, methyl myristate, methyl palmitate, methyl stearate, methyl eicosanoate, methyl docosanoate, lignoceric acid methyl ester, methyl hexaco-sanoate, methyl octacosanoate, and triaconta-noic acid methylester. Alternatively, alkanes or fatty acids may also be used. The final concentration of each compound in the mixture should be between 0.4 and 0.8 mg/mL of chloroform. 

A mixture of 4.98 g of acetoacetic acid N-benzyl-N-methylaminoethyl ester, 2.3 g of aminocrotonic acid methyl ester, and 3 g of m-nitrobenzaldehyde was stirred for 6 hours at 100°C in an oil bath. The reaction mixture was subjected to a silica gel column chromatography (diameter 4 cm and height 25 cm) and then eluted with a 20 1 mixture of chloroform and acetone. The effluent containing the subject product was concentrated and checked by thin layer chromatography. The powdery product thus obtained was dissolved in acetone and after adjusting the solution with an ethanol solution saturated with hydrogen chloride to pH 1 -2, the solution was concentrated to provide 2 g of 2,6-dimethyl-4-(3 -nitrophenyl)-1,4-dihydropyridlne-3,5-dicarboxylic acid 3-methylester-5- -(N-benzyl-N-methylamino)ethyl ester hydrochloride. The product thus obtained was then crystallized from an acetone mixture, melting point 136°Cto 140°C (decomposed). 

Finally, lV-(cyanomethyl)iminodiacetic acid was obtained from the ester of iminodiacetic acid and chloroacetonitrile as illustrated in Scheme l.10 The purified ester is hydrolyzed selectively at the methylester groups with zinc perchlorate in a 70% alcoholic solution and formation of the 1 1 complex (3) occurs. The substituted iminodiacetic acid is extracted with ether after zinc separation as ZnS by treatment with H2S, and crystallized in a chloroform ethanol solution. 

---