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2-Chloroacetic acid ethyl ester

In an initial step, 2-chloroacetic acid ethyl ester is reacted with formamide to give 5-methylimidazole-4-carboxylic acid ethyl ester. Then sodium in ammonia is used to convert that to 4-hydroxymethyl-5-methylimidazole-hydrochloride. Cysteamine HCI (HSCH2CH2NH2-HCI) is then reacted to give 4-(2-aminomethyl)-thiomethyl-5-methyl-imidazole dihydrochloride. Then N-cyanamido-5,5-dimethyl-dithio-carbonate (from cyanamid, KOH, CS2 and ((CH3)2S04) is reacted to give a further intermediate which is finally reacted with methylamine to give cimetidine. [Pg.1022]

Camphor 76-22-2 Chloroacetic Acid Ethyl Ester 105-39-5 Citraconic Anhydride 616-02-4... [Pg.1073]

Chloroacetic acid ethyl ester Potassium hydroxide Cysteamine Carbon disulfide Dimethyl sulfate... [Pg.342]

In an Initial step,2-chloroacetic acid ethyl ester is reacted with formamide to give 5-methyl-imidazole-4acid ethyl ester. Then sodium in ammonia is used to convert that to... [Pg.342]

A dissertation from 1943 [2] describes an interesting investigation concerning synthesis and properties of pure ether carboxylates. With metallic sodium and chloroacetic acid ethyl ester followed by saponification, ether carboxylates were made with the general formula... [Pg.314]

Chlorine Trifluoride Chlordacetic Acid Chloroacetic Acid, Ethyl Ester Chloroacetophenone Alpha-chloroacetophenone Omega-chloroacetophenone Chloroacetyl Chloride 5-Chloro-2-Aminotoluene... [Pg.33]

SYNS CHLOROACETIC ACID, ETHYL ESTER ETHYL CHLOROACETATE ETHYL-a-CHLOROACETATE ETHYL CHLOROETHANOATE ETHYL MONOCHLORACETATE ETHYL MONOCHLOROACETATE... [Pg.614]

Ethylmorpholine Ammonium Phosphate 105-39-5 Chloroacetic Acid Ethyl Ester... [Pg.1083]

CHLOROACETIC ACID, ETHYL ESTER (105-39-5) Combustible liquid (flash point 147°F/64°C oc also listed at 129°F/54°C). Violent reaction with oxidizers. Reacts with water, forming acetic acid. Violent reaction with alkaline earth metals, alkaline metals. Incompatible with sodium cyanide + heat. Attacks many metals in the presence of moisture, producing hydrogen gas. [Pg.285]

Beilstein Handbook Reference) Acetic acid, chloro-, ethyl ester AI3-19743 BRN 0506455 CCRIS 7747 Chloroacetic acid, ethyl ester EINECS 203-294-0 Ethyl chloracetate Ethyl chloroacetate Ethyl a-chloroacetate Ethyl chloroethanoate Ethyl monochloracetate Ethylester kyseliny chloroctove HSDB 408 NSC 8833 UN1181. Liquid mp = -21° bp 144.3° d = 1.1585 insoluble in H2O, soluble in CHCI3, CeHe, very soluble in EtOH, Et20, MezCO. [Pg.268]

Children (neonates/infants), 374 Chilling injury, 1565, 2788 Chimeric cytochrome P450 enzymes, 1632 Chinese, 2409, 2422 herbal medicine, 1303 medicine, 1399 method, 4043 traditional medicine, 1243 women, 2409 Chinotoxine, 615 CHIP-2 regulations, 3541 Chiral, 2109 Chiral selectors, 607 Chitosan, 1694, 1703 Chlamydia trachomatis, 1310 Chlorflavononin, 1824 Chloride channels, 4067, 4069,4096 Chloride conductance, 4066 Chloroacetic acid, 2896 Chloroacetic acid ethyl ester, 2896 Chlorodesmis major, 2903 Chloroform, 3371, 3385... [Pg.4177]

Chloroacetic acid (Monochloroacetic acid) (Chloroacetic acid ethyl ester) see Ethyl chloroacetate Chloroacetone (Chloro-2-propanone) Chloroacetonitrile 2-Chloroacetophenone (Tear gas)... [Pg.49]

Ethyl chloroacetate (Chloroacetic acid ethyl ester)... [Pg.66]

ETHYL CHLOROACETATE Ethyl Chloroacetate, Ethyl Chloroethanoate, Monochloroacetic Add,ethyl ester, Chioroacetic Acid,ethyl ester Combustible Liquid, III 3 0... [Pg.101]

Chlormolysis of tetraethylthiuram disulfide, 35, 55 Chloroacetamide, 30, 22 Chloroacetic acid, 39, 78 a-Chloroacetoacetic acid, ethyl ester, 33, 43, 45... [Pg.88]

Reactions of 3-substituted 2-(lV-phenylaminomethyl)piperazines with a slight excess of ethyl 2-chloroacetate under reflux afforded mixtures of 9-substituted 2-phenylperhydropyrido[l,2-a]pyrazin-3- and -4-ones, which could be separated by column chromatography [72JCS(P2)1374], When 2-[(3-trifluoromethylphenyl)aminomethyl]piperidine was heated with optically active ethyl 2-chloropropionate (87MIP1 91TA231), or lactic acid ethyl ester methanesulphonate (91TA231), the product was a C-9a epimeric mixture of 2-(3-trifluoromethylphenyl)-4-methylperhydropyrido[l,2-fl]-pyrazin-3-ones. The reaction between yV-methyl-2-piperidine-carboxamide and hydroxymaleic anhydride in pyridine resulted in 2,3-dimethyl-3-hydroxyperhydropyrido[l,2-a]pyrazine-l,4-dione (74CB2804). [Pg.247]

CHLOROACETIC ACID CHLORIDE see CEC250 CHLOROACETTC ACID, ETHYL ESTER see EHG500 CHLOROACETIC ACID METHYL ESTER see MF775 CHLOROACETIC ACID SODIUM SALT see SFU500 CHLOROACETIC ACID, soUd (UN 1751) (DOT) see CEAOOO... [Pg.1573]

Ethyl Cyanoacetate. Cyaitoacetic acid ethyl estert cyanoacetic ester ethyl cyanoethanoate malonic acid ethyl ester nitrile. CsH,N02 mol wt 113.12. C 53.09%. H 6.24%, N 12.39%, O 28.29%. CNCH2COOC2HS. Made by the interaction of sodium cyanide and chloroacetic acid and subsequent esterification of the cyanoacetic acid formed Kob -ler, Allen. Org. Syn. 3, 53 (1923) Inglis, ibid. 8, 74 (1928). [Pg.597]

In 1875, Mulder (43) extended the synthesis reaction of thiohydantoine to the ethyl ester and amide of chloroacetic acid. Claus (44) demonstrated the acidic properties of thiohydantoin and its ability to form metallic salts. [Pg.16]

Dichloroacetic acid is produced in the laboratory by the reaction of chloral hydrate [302-17-0] with sodium cyanide (31). It has been manufactured by the chlorination of acetic and chloroacetic acids (32), reduction of trichloroacetic acid (33), hydrolysis of pentachloroethane [76-01-7] (34), and hydrolysis of dichloroacetyl chloride. Due to similar boiling points, the separation of dichloroacetic acid from chloroacetic acid is not practical by conventional distillation. However, this separation has been accompHshed by the addition of a eotropeforming hydrocarbons such as bromoben2ene (35) or by distillation of the methyl or ethyl ester. [Pg.89]

Both esters have a sweet pungent odor and present a vapor inhalation ha2ard. They are rapidly absorbed through the skin and hydroly2ed to chloroacetic acid. The oral LD q for ethyl chloroacetate is between 50 and 100 mg/kg (52). [Pg.90]

Chloroacetate esters are usually made by removing water from a mixture of chloroacetic acid and the corresponding alcohol. Reaction of alcohol with chloroacetyl chloride is an anhydrous process which Hberates HCl. Chloroacetic acid will react with olefins in the presence of a catalyst to yield chloroacetate esters. Dichloroacetic and trichloroacetic acid esters are also known. These esters are usehil in synthesis. They are more reactive than the parent acids. Ethyl chloroacetate can be converted to sodium fluoroacetate by reaction with potassium fluoride (see Fluorine compounds, organic). Both methyl and ethyl chloroacetate are used as agricultural and pharmaceutical intermediates, specialty solvents, flavors, and fragrances. Methyl chloroacetate and P ionone undergo a Dar2ens reaction to form an intermediate in the synthesis of Vitamin A. Reaction of methyl chloroacetate with ammonia produces chloroacetamide [79-07-2] C2H ClNO (53). [Pg.90]

See other pages where 2-Chloroacetic acid ethyl ester is mentioned: [Pg.342]    [Pg.342]    [Pg.1621]    [Pg.1022]    [Pg.342]    [Pg.1621]    [Pg.1621]    [Pg.342]    [Pg.342]    [Pg.1621]    [Pg.1022]    [Pg.967]    [Pg.234]    [Pg.188]    [Pg.597]    [Pg.268]    [Pg.342]    [Pg.1621]    [Pg.1621]    [Pg.1013]    [Pg.311]    [Pg.2896]    [Pg.157]    [Pg.789]    [Pg.1430]    [Pg.3386]    [Pg.128]    [Pg.69]    [Pg.268]    [Pg.268]    [Pg.588]   


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2-Chloroacetic acid, acidity

Chloroacetate

Chloroacetate ester

Chloroacetates

Chloroacetic

Chloroacetic acid

Ethyl chloroacetal

Ethyl chloroacetate

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