1- Chloro-2-fluoropropane

Chloro-2-fluoropropane can be produced in high yield (75 %) when the addition of hydrogen fluoride to 2-chloropropene is carried out in nitrobenzene at 14"C for ten minutes without further reaction to provide 2,2-difluoropropane. ... 

With bromine trifluonde and 1% tin tetrachloride as a catalyst, 1,3-dichloro 2-fluoropropane gives 1,2,3 tnfluoropropane Without the catalyst, l-chloro-2,3 difluoropropane provides a four-component product mixture 1,2,3-trifluoro-propane, 3-chloro-l,l,2-tnfluoropropane, l-chloro-2,2,3-tnfluoropropane, and 1,1,2,3-tetrafluoropropane [9] (equations 7 and 8)... 

With Freon 112 or 113 as a solvent, fluonnation of pnmary butyl halides with bromine trifluonde can give mixtures of primary and secondary fluorides When 1,4 dibromobutane is the substrate, 93% l-bromo-4-fluorobutane and 1% 1-bro-mo-3-fluorobutane is obtained, with 1,4 dichlorobutane, the product contains 65% l-chloro-3-fluorobutane and 35% 1-chloro 4 fluorobutane When 4-bromo- or 4-chlorobutyl trifluoroacetate is used, the ratio of 4-fluorobutyl tnfluoroacetate to 3 fluorobutyl trifluoroacetate is 1 4 The effect of solvent is measured in another set of experiments When the reaction of bromine trifluonde and l,3-dichloro-2-fluoropropane in either Freon 113 or hydrogen fluoride is allowed to proceed to 40% conversion, the product mixture has the composition shown m Table 1 [/O] When 1 chloro 2,3-dibromopropane is combined with one-third of a mole of bromine trifluonde, both 1 bromo 3 chloro-2-fluoropropane and l-chloro-2,3-di-fluoropropane are formed [//] (equation 10)... 

To 61 % HF/pyridine (30 mL) was added 2-(chloromcthyl)oxirane (14 g, 0.15 mol) over 90 min at 0 C. The product was isolated 5 min after the addition was completed, either by extraction with CC14 or by quenching the mixture with ice water, followed by extraction with CHC13. The organic layer was separated, dried (MgS04 or Na2S04) and the solvents distilled off and l-chloro-3-fluoropropan-2-ol isolated by distillation at reduced pressure yield 8.4 g (50%) bp 50"C/l Torr. 

Chloromethyl)oxirane (3) affords 1,3-difluoro- and l-chloro-3-fluoropropan-2-ol (4 and 5) on reaction with potassium hydrogen fluoride in diethylene glycol.76 There is no reaction when potassium fluoride is used which indicates that the epoxy ring in 3 is opened by the hydrogen fluoride present in potassium hydrogen fluoride and later the chlorine is exchanged for fluorine. 

Hexachlor6-3-fluoropropane (CHCI2CCI2CCI2F).30 In a 1-1. flask, a mixture of 1160 g. of 1,1,2,2,3,3,3-heptachloropropane and 740 g. of antimony trifluorodichloride is vigorously stirred so that the temperar ture does not exceed 50°. After the mixture has cooled to 30°, it is slowly heated to 130-140° and maintained at this temperature for five hours. It is then cooled, poured into water, washed with hydrochloric acid—to remove antimony salts—then with water, anchdried. The yield is 907 g. of reaction product containing approximately 60 g. of 1,1,2,2-tetrachloro-3,3,3-trifluoropropane (b.p. 130°), 315 g. of 1,1,2,2,3-penta-chloro-3,3-difluoropropane (b.p. 168°), and 435 g. of 1,1,2,2,3,3-hexa-chloro-3-fluoropropane (b.p. 210°). 

How does benzene react with l-chloro-2-fluoropropane under the catalysis by strong Lewis acids such as boron trifluoride or aluminum chloride What is compound D ... 

IUPAC name bromomethane 1 -fluoropropane 2-iodobutane 2-chloro-2-methylpropane... 

A more detailed procedure was given for the conversion of 2- chloromethyl)oxirane (epi-chlorohydrin) into a mixture of 1,3-difluoropropan-2-ol (1,39 %) and 1 -chloro-3-fluoropropan-... 

To a hoi (oil bath temperature 90 C), stirred solution of PhjP (26.2 g, 0.1 mol) in anhyd benzene (110 mL) was added dropwise j-chloro-3-fluoropropan-2-one (5 ll.Og, 0.1 mol). After a while, the phosphonium chloride precipitated. At the end of the addition, stirring was continued at 90 C for 3 h. (1-Fluoro-acetonyl)triphenylphosphoniuni chloride (6) was filtered off from the cold mixture, washed with benzene, and dried under vacuum yield 28,7g (77%) mp 187 C (dec.). 

A few other side compounds are also produced during pyrolysis including hexafluoropropylene, perfluoro-cyclobutane, and octafluoroisobutylene, 1-chloro-1,1,2,2-tetrafluoroethane, 2-chloro-1,1,1,2,3,3-hexa-fluoropropane and a small amount of highly toxic perfluoroisobutylene. 

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