Fluoropropane

If the two substituents are not identical, one may still focus on the interaction of the group MO s of the substituents and those of the — CH2— CH2 - fragment. As an example, we will consider 1-fluoropropane. This molecule constitutes system where a hydrogen bond determines conformational preference and merits special attention. This hydrogen bond represents a bonding situation which can be classified under the heading of nonbonded attractive interactions. 

Consider the molecule 1-fluoropropane dissected in the manner shown below. First, we consider the sigma nonbonded interaction between methyl and fluorine and we construct the group MO s of the CH3—F fragment as shown by the interaction diagram of Fig. 19. 

Fig. 19. The sigma group MO s spanning the substituents in 1 fluoropropane as constructed from the sigma MO s of a CH bond and the fluorine sigma lone pair AO. Net stabilization results due to the Fpx-4>2 interaction...

Fluorination by cleavage of a C-C bond has been achieved in the case of small carbocyclic rings. Thus, cyclopropane is transformed to 1-fluoropropane (1) by 70% hydrogen fluoride/ pyridine at room temperature (75 % yield).31-6162 See also Houben-Weyl, Vol. 5/3, pp 114-115. 

IUPAC name bromomethane 1 -fluoropropane 2-iodobutane 2-chloro-2-methylpropane... 

C3H7F 1-fluoropropane 460-13-9 5.920E-h09 39.850 3033 C4H606 tartaric acid 87-69-4 1.018E+10 68.680... 

Fluorination is difficult to control, but if propane were monofluorinated, the product mixture would reflect the ratio of the types of hydrogens six 1° H to two 2° H, or 3 1 ratio, giving 75% 1-fluoropropane and 25% 2-fluoropropane. 

Then, the vertex-weighted distance matrix D of 1-fluoropropane is... 

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