Chloralose

Pellotine is a convulsant in the frog and cat. Clerc, Janot and Paris, state that the intravenous lethal dose in dogs is 10 mgm./kilo. In chloralosed dogs 5 mgm./kilo slowed the heart and caused a fall in blood pressure the effects lasted for a few minutes and resembled those due to acetylcholine they were inhibited by atropine and increased by yohimbine and ergotamine. A few injections of this dose at short intervals produced convulsions and this effect was inhibited by phenobarbitone. 

FIGURE 9.15 In vivo effec ts o f P-adreno cep tor partial agonis ts o f differing in trinsic efficacy. Changes in heart rate (increases in beats/min) shown in anesthetized cats. Chloralose/pento barbital anesthesia (filled circles) yield low basal heart rates, while urethane/pen to barbital anaesthesia (open circles) yields high basal heart rates. Responses to (in order of descending relative intrinsic efficacy) (a) pirbuterol, (b) prenalterol, and (c) pindolol. Redrawn from [50],... 

Xi, M. C., Liu, R. H., Yamuy, J., Morales, F. R. Chase, M. H. (1997). Electro-physiological properties of lumbar motoneurons in the alpha-chloralose-anesthetized cat during carbachol-induced motor inhibition. J. Neurophysioi 78, 129-36. 

More successful applications of periodate oxidation to substituted sugars were made employing the sugar phosphates and phosphoric acids,63 66 the chloraloses, 62 70 the benzyl ethers of sugars,71 72 a dimethyleneoxy sugar,73... 

Anesthesia with light barbiturate, halothane or a-chloralose. 

Ueki, M., Mies, G. and Hossmann, K. A. Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat. Acta Anaesthesiol. Scand. 36 318-322,1992. 

Chlomethoxyfen phenyl ether Chloralose sugar derivate... 

Chloral chloretoxyfos, chloralose, DDT, dichlorvos, dicofol, methoxychlor, naled, plifenate, trichlamide, trichlorfon, triforine Chlordane heptachlor Chlordene chlordane Chlorine cyanide see cyanogen chloride Chloro acetaldehyde nipyraclofen, oxabetrinil Chloro acetone pymetrozine Chloro acetonitrile thicyofen... 

Rabbits are anesthetized with methohexital and alpha-chloralose and ventilated mechanically. After establishing an intravenous port, the animals receive the alphai-agonist methoxamine at 15 fig/kg/min, a dose that should have only a slight effect on systemic arterial blood pressure. The ECG is measured using standard limb leads and an monophasic action potential... 

Adult cats of either sex are anesthetized with a-chloralose, 80 mg/kg, and pentobarbital 7 mg/kg, given intraperitoneally. Cannulas are placed in the left femoral vein and artery for drug injection and recording blood pressure and heart rate. The lungs are mechanically ventilated through a tracheostomy and a small animal ventilator set to deliver 15 ml/kg tidal volume and 20 breaths/min. 

The presence of abnormal colours may indicate the presence of inorganic pigments (e.g. copper, nickel, or cobalt salts), dyestuffs from tablets, capsules, medicines, pesticides, and rodent baits, especially those containing warfarin, reserpine, chloralose, or diphenadione. Common rat-bait coloms are blue, green, or red and are usually associated wifti oafrneal or cereal grain. 

CHLORALLYLENE see AGB250 CHLORALONE see CDPOOO CHLORALOSANE see GFAOOO a-CHLORALOSE see GFAOOO CHLORAMBUCIL see CD0500... 

D-glucitol hexanicotinate sorbinicate. GlUCObay acarbose. glucochloralose chloralose. 

Despite their ubiquitous distribution in plants, manmade glucosidic derivatives of alcohols or phenols are rarely prepared in medicinal chemistry. An old-timer is the sedative-hypnotic a-chloralose (Figure 38.24) which is presently used only as a surgical anesthetic for laboratory animals. 

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