Chitosan superparamagnetic iron

Juang, J.H., Wang, J.J., Shen, C.R., Kuo, C.H., Chien, Y.W., Kuo, H.Y., et al Magnetic Resonance Imaging of Transplanted Mouse Islets Labeled With Chitosan-Coated Superparamagnetic Iron Oxide Nanoparticles. Transpl. P. 42, 2104—2108... 

Cheong, S. J., Lee, C. M., Kim, S. L. et al. 2009. Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. Int. J. Pharm. 372 169-176. 

E.-Y. Chung, H.-M. Kim, G.-H. Lee, B.-K. Kwak, J.-S. Jung, H.-J. Kuh, J. Lee, Design of deformable chitosan microspheres loaded with superparamagnetic iron oxide nanoparticles for embolotherapy detectable by magnetic resonance imaging. Carbohydrate Polymers 90 (2012) 1725-1731. 

Superparamagnetic iron oxide NPs encapsulated within chitosan Biomedical applications [213]... 

Superparamagnetic iron oxide NPs-loaded chitosan-Unoleic acid nanopeiiticles As an effective hepatocyte-taigeted gene delivery system [223]... 

Kim EH, Ahn Y, Lee HS. Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan. J Alloys Compd. 2007 434 35 633-6. 

Recently, Reddy et al. demonstrated that labeling of mesenchymal stem cells (MSCs) with superparamagnetic iron oxide nanoparticles (SPlONs) coated with chitosan did not alter the proliferation, surface marker expression or differentiation capacity of MSCs [92]. For comparison, Resovist, a commercially available MR contrast agent coated with carboxydextran, showed alteration to the chondrogenesis capacity of MSC. In addition, the chitosan-coated SPION-loaded MSCs did not show any toxic effects in viability studies over a 3-week period. Further, in vivo MR imaging of the chitosan-coated SPION-loaded MSCs injected into the brain of an ischemic brain rabbit model enabled the tracking of the stem cells for up to 2 weeks (Fig. 2). 

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