Chitosan/poly graft copolymers

Galactosylated chitosan prepared from lactobionic acid and chitosan with l-ethyl-3-(3-dimethylaminopropyl)-carbodiimideand N-hydroxysuccinimide was a good extracellular matrix for hepatocyte attachment [155] (Fig. 4). Furthermore, graft copolymers of galactosylated chitosan with poly(ethylene glycol) or poly(vinyl pyrrolidone) were useful for hepatocyte-targeting DNA carrier [156,157]. [Pg.170]

Keywords Chitosan Graft copolymers Poly(ethylene oxide) Polymer brushes Surface forces... [Pg.124]

Graft copolymers of poloxamers and either poly(acrylic acid) or chitosan change from a sol to a gel at temperature above 37 °C. The appearing gel forms a stable matrix that can retain a drag for its sustained release. The triblock copolymer consisting of polyethylene oxide)-poly(/-lactide)-poly(ethylene oxide) (PEO-PLLA-PEO) is also temperature-sensitive but shows an opposite gellation property. At low... [Pg.384]

Gorochovceva N, Makuska R (2004) Synthesis and study of water-soluble chitosan-O-poly (ethylene glycol) graft copolymers. Eur Polym J 40 685-691... [Pg.41]

Saito FI, Wu XD et al (1997) Graft copolymers of poly(ethylene glycol) (PEG) and chitosan. Macromol Rapid Commun 18 547-550... [Pg.41]

Chen C, Cal GQ et al (2011) Chitosan-poly(epsllon-caprolactone)-poly(ethylene glycol) graft copolymers synthesis, self-assembly, and drug release behavior. J Biomed Mater Res A 96A 116-124... [Pg.43]

Graft copolymers are polymers produced when molecular fragments belonging to others polymers have been inserted into their side chains (Hazer and Steinbiichel 2007). The condensation reaction between the carboxy-terminal groups of certain PHAs poly[(/ )-3-hydroxybutyrate] poly[(/ )-3-hydroxybutyrate-co-(l )-3-hy-droxyvalerate] or PHO and the amine function of chitosan resulted in grafting of PHA polymers onto chitosan (Fig. 2). These grafted polymers formed opaque, viscous solutions in water and, once dried, afforded strong elastic films (Yalpani et al. 1991 Arslan et al. 2007). [Pg.163]

Synthesis and Derivatization of Chitosan/Poly(ethylenimine) Graft Copolymers...71... [Pg.69]

In this chapter, we review the latest advances in chitosan modification, with a special focus on the synthesis and functional properties of chitosan/poly(ethylenimine) (CP/PEI) graft copolymers and their derivatives as pDNA carriers. We also address the prospects and challenges of the practical... [Pg.69]

A similar methodology was applied by Xiang et al. (2009) for the synthesis of chitosan grafted with poly(L-tryptophan) chains (Scheme 15.22). Deacetylated chitosan (deacetylation degree of amino groups 75%) was employed as a multifunctional macroinitiator for the polymerization of the L-tryptophan-NCA in ethyl acetate solutions leading to the synthesis of chitosan-g-poly(L-tryptophan) graft copolymers. The products were analyzed by NMR and IR spectroscopy. [Pg.478]

Xiang, Y, Si, J., Zhang, Q. et al. (2009) Homogeneous graft copolymerization and characterization of novel artificial glycoprotein Chitosan-poly(L-tryptophan) copolymers with secondary structural side chains. Journal of Polymer Science Part A Polymer Chemistry, 47,925-934. [Pg.488]

Huang, R., Chen, G., Sun, M., and Gao, C. 2006. A novel composite nanofiltration (NF) membrane prepared from graft copolymer of trimethylaUyl ammonium chloride onto chitosan (GCTACC)/poly(acrylonitrile) (PAN) by epichlorohydrin cross-linking. Carbohydr. Res. 341 2777-2784. [Pg.186]

With the purpose of conferring thermosensitivity to chitosan-based hydrogels. Park et al. proposed the grafting of carboxylic acid-terminated poly(ethylene oxide-h-propylene oxide) block copolymer (Pluronic) onto the primary amine of chitosan, mediated by EDC coupling agent [102]. With the same purpose, Wang et al. grafted poly(N-isopropyl acrylamide) (NiPAM) chains onto chitosan by the copolymerization of acrylic acid-derivatized chitosan and N-isopropylacrylamide (NIPAAm) in aqueous solution [103]. [Pg.28]

Liu L, Xu X et al (2009) Synthesis and self-assembly of chitosan-based copolymer with a pair of hydrophobic/hydrophilic grafts of polycaprolactone and poly(ethylene glycol). Carbohydr Polym 75 401 07... [Pg.41]

S. Mao, X. Shuai, F. Unger, M. Wittmar, X. Xie, T. Kissel, Synthesis, characterization and cytotoxicity of poly (ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials 26 (32) (2005) 6343-6356. [Pg.88]

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