Chitosan—glycerol phosphate gels

Hoemann CD, Chenite A, Sun J, Hurtig M, Serreqi A, Lu Z, Rossomacha E, Buschmann MD (2007) Cytocompatible gel formation of chitosan-glycerol phosphate solutions supplemented with hydroxyl ethyl cellulose is due to the presence of glyoxal. J Biomed Mater Res A 83 521-529... 

Filion, D., Buschmann, M.D., 2013. Chitosan-glycerol-phosphate (GP) gels release freely diffusible GP and possess titratable fixed charge. Carbohydrate Polymers 98,813-819. 

A reverse thermo-gelation property system was generated using chitosan and glycerol phosphate di-sodium salt (Chenite et al., 2000). The aqueous solution of this mixture behaved as sol at normal temperatures and showed gel phase transition when the temperature was increased to 37 C. The structuring effect of glycerol on water... 

Kim and coworkers [158] developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol phosphate (GP). The phase transition behaviors of chitosan and GP solution were characterized as a function of temperature. The chitosan and GP solutions were shown to form a sol at room temperature, and the chitosan solution with 10-20 wt% concentrations were found to undergo sol-to-gel phase transitions as the temperature was increased. In situ gel forming implant in vivo was successfully fabricated by simple subcutaneous injection of Chitosan and GP solutions with demineralized bone matrix (DBM). 

Recently, alkylchitosans were prepared giving interesting amphiphilic properties due to physical network formed by hydrophobic interaction between alkyl grafted chains they also have surface activity. [104-106] Grafting of N-isopropylaciylamide (NIPAm) or a ethylene oxide-propylene oxide copolymer (POEP) on chitosan produces thermosensitive polymers which may have new applications in controlled release. [107,108]An other thermosensitive systems was obtained when a glycerol-2-phosphate solution is added to a solution of chitosan up to pH around 7 the gel forms over 37°C. [109-111]... 

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