Chirality supercritical fluid chromatography

Hsieh, Y. et al., Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples, Rapid Commun. Mass Spectrom., 19(21), 3037, 2005. 

Mukherjee, P.S. and Cook, S.E. (2006) A feasibility study on direct assay of an aqueous formulation by chiral supercritical fluid chromatography. J Pharm Biomed Anal, 41 (4), 1287-1292. 

De Klerck K, Mangelings D, Clicq D, De Boever F, Vander Heyden Y. Combined use of isopropylamine and trifluoro-acetic acid in methanol-containing mobile phases for chiral supercritical fluid chromatography. J. Chromatogr. A 2012 1234 72-79. 

Supercritical fluid chromatography (SFC) provides a means of minimizing the limitations of CSPs developed for FC while retaining the impressive chiral selectivity that has been achieved through the evolution of CSPs during the past two decades [6, 7]. The use of supercritical fluids as eluents for chromatographic separations was... 

The submitters determined the crystalline hydroxy esters to be >99.9% diastereomerically pure by supercritical fluid chromatography (EMdiol silica column and a Chiralcel (+) OD-(H) column (Chiral... 

Beside the use of MIPs in conventional HPLC, Mi-polymers may also be established in supercritical fluid chromatography, which is characterized by faster equilibration times combined with the use of the environmental friendly C02 as mobile phase. Although preliminary results show relatively broad peaks, chiral separation could be performed based on polymers imprinted with an enantiomer. However, the long-term stability of the photochemically generated polymers seems to be a problem [89]. 

Donnecke, J. et ah. Evaluation of a vancomycin chiral stationary phase in packed capillary supercritical fluid chromatography, J. Microcol. Sep., 11, 521, 1999. 

Svensson, L.A. and Owens, P.K., Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases. Analyst, 125, 1037, 2000. 

Matthijs, N., Maftouh, M., Vander Heyden, Y. Chiral separation strategy in polar organic solvent chromatography and performance comparison with normal-phase liquid and supercritical-fluid chromatography. J. Sep. Sci. 2006, 29, 1353-1362. 

Zhao, Y., Woo, G, Thomas, S., Semin, D., Sandra, P. Rapid method development for chiral separation in drug discovery using sample pooling and supercritical fluid chromatography-mass spectrometry. J. Chromatogr. A 2003, 1003, 157-166. 

ViUeneuve, M.S., Anderegg, R.J. Analytical supercritical fluid chromatography using fully automated column and modifier selection valves for the rapid development of chiral separations. J. Chromatogr. A 1998, 826, 217-225. 

Maftouh, M., Granier-Loyaux, C., Chavana, E., Marini, J., Pradines, A., Vander Heyden, Y., Picard, C. Screening approach for chiral separation of pharmaceuticals Part in. Supercritical fluid chromatography for analysis and purification in drug discovery. J. Chromatogr. A 2005, 1088, 67-81. 

Enantioselective separation by supercritical fluid chromatography (SFC) has been a field of great progress since the first demonstration of a chiral separation by SFC in the 1980s. The unique properties of supercritical fluids make packed column SFC the most favorable choice for fast enantiomeric separation among all of the separation techniques. In this chapter, the effect of chiral stationary phases, modifiers, and additives on enantioseparation are discussed in terms of speed and resolution in SFC. Fundamental considerations and thermodynamic aspects are also presented. 

Supercritical fluid chromatography using chiral stationary phases... 

Phinney KW, Sub- and supercritical fluid chromatography for enantiomer separations, in Chiral Separation Techniques A Practical Approach, (Suhramanian G, Ed.), p. 299, VCH Verlag, Weinheim, Germany (2001). 

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