Chip Electrospray Mass Spectrometry

Electrospray ionization-mass spectrometry (ESI-MS) Electrospray mass spectrometry Electrospray emitter on-chip Chip electrospray mass spectrometry... 

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Yang YN, Li C Kameoka J, Lee KH, Craighead HG (2005) A polymeric microchip with integrated tips and in situ polymerized monolith for electrospray mass spectrometry. Lab Chip 5 869... 

Wang C., Oleschuk R., Ouchen F., Li J., Thibault R, and Harrison D.J. (2000), Integration of immobilized trypsin bead beds for protein digestion within a micro-fluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface, Rapid Commun. Mass Spectrom. 14(15), 1377-1383. 

Tan, A., Benetton, S., and Henion, J. D. (2003). Chip-based solid-phase extraction pretreatment for direct electrospray mass spectrometry analysis using an array of monolithic columns in a polymeric substrate. Anal. Chem. 75, 5504—5511. 

Chartogne, A. Tjaden, U.R. Van der Greef, J. A Lrcc-llow Electrophoresis Chip Device for Interfacing Capillary Isoelectric Focusing On-line with Electrospray Mass Spectrometry, Rapid Commun. Mass Spectrom. 14, 1269-1274 (2000). 

Yang, Y., Li, C., Lee, K. H., and Craighead, H. G, Coupling on-chip sohd-phase extraction to electrospray mass spectrometry through an integrated electrospray tip. Electrophoresis, 26, 3622-3630, 2005. 

Yue, G.E., Roper, M.G., Jeffery, E.D., Easley, C.J., Balchunas, C., Landers, J.R, Ferrance, J.P., Glass microfluidic devices with thin membrane voltage junctions for electrospray mass spectrometry. Lab Chip, 5, 619-627, 2005. 

Rob, T., Wilson, D.J. (2009) A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry. Journal of the American Society for Mass Spectrometry, 20 (1), 124-130. 

Rob, T Wilson, D.J. (2009) A Versatile Microfluidic Chip for Millisecond Time-scale Kinetic Studies by Electrospray Mass Spectrometry. J. Am. Soc. Mass Spectrom. 20 124-130. 

Fazar, I. M., Ramsey, R. S., and Ramsey, J. M. (2001). On-chip proteolytic digestion and analysis using wrong-way-round electrospray time-of-flight mass spectrometry. Anal. Chem. 73, 1733-1739. 

Fion, N., Gellon, J. O., Jensen, H., and Girault, H. H. (2003). On-chip protein sample desalting and preparation for direct coupling with electrospray ionization mass spectrometry. ]. Chromatogr. A 1003, 11-19. 

Xue, Q., Dunayevskiy, Y. M., Foret, F., and Karger, B. L. (1997). Integrated multichannel microchip electrospray ionization mass spectrometry analysis of peptides from on-chip tryptic digestion of melittin. Rapid Commun. Mass Spectrom. 11, 1253 — 1256. 

Very low flow electrospray is called nanoelectrospray [26] where the samples are infused into the mass spectrometer at the nanoliter flow rate range. The infusion of a few microliters will result in a stable signal for more then 30 min, using pulled capillaries or chip-based emitters [27]. With infusion, signal averaging allows to improve the limit of detection in tandem mass spectrometry. Nanoelectrospray is particularly important in combination with nanoflow liquid chromatography or chip-based infusion for the analysis of peptides and proteins. 

Licklider, L. Wang, X.-Q. Desai, A. Tai, Y.-C. Lee, T. D. 2000. A micro-machined chip-based electrospray source for mass spectrometry. Anal. Chem., 72,367-375. 

Benetton, S., Kameoka, J., Tan, A., Wachs, T., Craighead, H., Henion, J.D., Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection. Anal. Chem. 2003, 75, 6430-6436. 

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