Chemotherapy alkylating agents

Alkylating agents are also mutagenic substances that have been used in cancer chemotherapy. Alkylating agents such as nitrogen or... 

MOPP and other combined chemotherapy including alkylating agents (Suppl. 7 1987)... 

To translate this approach into clinical scenarios, the risk-benefit assessment of chemotherapy administration in already immunocompromised patients would favor situations in which cytotoxic drugs are indicated anyhow, such as in AIDS-related lymphomas, where alkylating agents are part of the standard regimens. 

Each category of chemotherapy drugs has similar side effects. Anthracyclines cause cardiac toxicity, which is related to the cumulative dose. Tubulin interactive agents are associated with neuropathy and ileus. Alkylating agents are associated with secondary malignancies. 

Risk factors for the development of AML include exposure to environmental toxins, Hispanic ethnicity, and genetics.6 Of greater concern is the increased prevalence of AML as a secondary malignancy, resulting from chemotherapy and radiation treatment for other cancers. Alkylating agents, such as ifosfamide and cyclophosphamide, and topoisomerase inhibitors, such as etoposide, are linked to an increased risk of myelodysplastic syndrome (MDS) and AML.8... 

Patients who present with symptomatic disease will be started on therapy. Two regimens used are VAD and melphalan and prednisone (MP). VAD like chemotherapy regimens are used most often in transplant candidates because it avoids the alkylating agent melphalan, thus minimizing damage to the stem cell compartment. These two regimens produce equivalent response rates of approximately 50% to 70% in previously untreated patients with myeloma (see Table 93-4).35>36... 

Cyclophosphamide (Cytotoxin) Alkylating agent cancer chemotherapy transplant rejection rheumatoid arthritis Decreased Ts cells, B cells, and NK cells... 

Besides being used as an alkylating agent in cancer chemotherapy, cyclophosphamide is a unique drug when used as an immunosuppressant. First, it is the most powerful of all such drugs. Second, it kills proliferating cells, and evidently alkylates a certain region of... 

Chemotherapy, eombined, including alkylating agents (see MOPP and other eombined ehemotherapy ineluding alkylating agents) Chloral... 

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