Chemokines neutrophil recruitment

Laan M, Cui ZH, Hoshino H, Lotvall J, Sjostrand M, Gruenert DC, Skoogh BE, Linden A Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol 1999 162 2347-2352. 

Chemokines and Chemokine Receptor Involvement in Neutrophil Recruitment... 

Subfamily Chemokine receptor Major hgands Involved in neutrophil recruitment ... 

Godaly G, Bergsten G, Hang L, Fischer H, Frendeus B, Lundstedt AC, Samuelsson M, Samuelsson P, Svanborg C Neutrophil recruitment, chemokine receptors, and resistance to mucosal infection. J Leukoc Biol 2001 69 899. 

McColl SR, Clark-Ijewis I Inhibition of murine neutrophil recruitment in vivo by CXC chemokine receptor antagonists. J Immunol 1999 163 2829. 

Tateda K, Moore TA, Newstead MW, Tsai WC, Zeng X, Deng JC, Chen G, Reddy R, Yamaguchi K, Standiford TJ Chemokine-dependent neutrophil recruitment in a murine model of Legionella pneumonia Potential role of neutrophils as immunoregulatory cells. Infect Immun 2001 69 2017. 

In addition to their direct antimicrobial activity [15] defensins, whose functional overlap with chemokines has recently been confirmed, enhance phagocytosis, promote neutrophil recruitment, boost the production of proinflammatory cytokines and regulate complement activation, thus upregulating innate host inflammatory defenses [15]. They also contribute to adaptive immune responses by selectively attracting immature DCs, CD8+ T cells,... 

Hall LR, Diaconu E, Patel R, Pearhnan E. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J Immunol 2001 166 4035-4041. 

Frevert CW, Huang S, Danaee H, Paulauskis JD Kobzik L Functional charactenza-tion of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation J Immunol 1995, 154 335-344... 

The modulation of neutrophil recruitment might also be targeted indirectly, for the chemotactic responses of these cells are relatively sensitive to alterations within the stress-induced p38 mitogen-activated protein (MAP) kinase cascade (49). A number of recent publications have highlighted a potential therapeutic role for inhibitors of this pathway in airway disease (49-51). Preadministration of the p38 MAPK inhibitors before LPS intratracheal challenge in mice reduced the numbers of neutrophils in the airway. This effect was not due to a reduction in the levels of these chemokines following p38 MAPK inhibition. Nick and... 

Schelenz S, Smith DA, Bancroft GJ. Cytokine and chemokine responses following pulmonary challenge with Aspergillus fumigatus obhgatory role of TNF-alpha and GM-CSF in neutrophil recruitment. Med Mycol 1999 37 183-194. 

Neutrophils are conspicuous by their absence. During the process of inflammation, a rapid transformation of the milieu in the pleural space occurs (8-10). The pleural mesothelium initiates a cascade of events that lead to the release of chemokines, the recruitment of phagocytic cells from the vascular compartment into the pleural space, and changes in pleural permeability that facilitate an organized series of events (8). 

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